Tag Archives: scott

New ways to treat solid tumors using protein — ScienceDaily

As EphA3 is present in normal organs only during embryonic development but is expressed in blood cancers and in solid tumors, this antibody-based approach may be a suitable candidate treatment for solid tumors. The researchers from Monash University and Ludwig Cancer Research, in Australia, and KaloBios Pharmaceuticals, in the US, have had their findings published in the journal Cancer Research. The team, led jointly by the late Professor Martin Lackmann, from the School of Biomedical Sciences at Monash; and Professor Andrew Scott, from Ludwig Cancer Research, has found that even if tumor cells do not have this molecule they can thrive by recruiting and taking advantage of supporting EphA3-containing cells in the tumor micro-environment…

New ways to treat solid tumors using protein

As EphA3 is present in normal organs only during embryonic development but is expressed in blood cancers and in solid tumors, this antibody-based approach may be a suitable candidate treatment for solid tumors. The researchers from Monash University and Ludwig Cancer Research, in Australia, and KaloBios Pharmaceuticals, in the US, have had their findings published in the journal Cancer Research…

Cancer cells supported by normal cells in and near tumors

The targeting of interactions between cancer cells and their environment together with the traditional tactic of directly targeting cancer cells with drugs or radiation is an important new front in the fight against cancer. The study was conducted by two CSHL scientists from different disciplines who joined forces in the Laboratory’s tradition of collaborative research. Mikala Egeblad, Ph.D., is an expert in the analysis of interactions between cancer cells and normal cells, and Scott Powers, Ph.D., is an expert in applying genome-wide "big-picture" methods to the study of cancer…

‘Molecular flashlight’ illuminates brain tumors in mice

The researchers altered the amino acid sequence of a cystine knot peptide — or knottin — derived from the seeds of the squirting cucumber, a plant native to Europe, North Africa and parts of Asia. Peptides are short chains of amino acids that are integral to cellular processes; knottin peptides are notable for their stability and resistance to breakdown. The team used their invention as a "molecular flashlight" to distinguish tumors from surrounding healthy tissue. After injecting their bioengineered knottin into the bloodstreams of mice with medulloblastomas, the researchers found that the peptide stuck tightly to the tumors and could be detected using a high-sensitivity digital camera. …

Frequent heartburn may predict cancers of the throat and vocal cord

"Previous studies examining gastric reflux and cancers of the head and neck have generated mixed results," said Scott M. Langevin, Ph.D., postdoctoral research fellow at Brown University in Providence, R.I. "Most of those studies had either few numbers of cases or they were not adjusted for confounding factors…