Tag Archive spring

Study revises theory of how PTEN, a critical tumor suppressor, shuts off growth signals

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Today, scientists at Cold Spring Harbor Laboratory (CSHL) publish new evidence explaining precisely how the protein encoded by PTEN (called PTEN) works — specifically, how it is recruited to particular locations in our cells where pro-growth signals need to be shut off. The new evidence, assembled by a team led by CSHL Associate Professor Lloyd Trotman, contradicts a long-held assumption about PTEN function, and could help scientists design more effective drugs to counteract cancer’s hallmark trait, uncontrolled cellular growth…

How antioxidants can accelerate cancers, and why they don’t protect against them — ScienceDaily

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source : http://www.sciencedaily.com/releases/2014/07/140710094434.htm

Overexpression of splicing protein in skin repair causes early changes seen in skin cancer

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"It has been noted that cancer resembles a state of chronic wound healing, in which the wound-healing program is erroneously activated and perpetuated," says Professor Adrian Krainer of Cold Spring Harbor Laboratory (CSHL). …

Cancer cells supported by normal cells in and near tumors

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The targeting of interactions between cancer cells and their environment together with the traditional tactic of directly targeting cancer cells with drugs or radiation is an important new front in the fight against cancer. The study was conducted by two CSHL scientists from different disciplines who joined forces in the Laboratory’s tradition of collaborative research. Mikala Egeblad, Ph.D., is an expert in the analysis of interactions between cancer cells and normal cells, and Scott Powers, Ph.D., is an expert in applying genome-wide "big-picture" methods to the study of cancer…