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new role for estrogen in pathology of breast cancer discovered

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The University of Illinois team reports its findings in the journal Oncogene. …

Promising new cancer therapy uses molecular ‘Trash Man’ to exploit a common cancer defense

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Cancer therapies cause unwanted proteins to accumulate in cancer cells, which can trigger a form of cell suicide known as apoptosis. To survive, the cells break down the excess proteins through autophagy, from a Greek term meaning “self eating.” In a study recently published in the journal Molecular and Cellular Biology, scientists induced autophagy using the anti-tumor drug obatoclax while simultaneously blocking the production of p62 using a drug known as a cyclin-dependant kinase (CDK) inhibitor. …

Gene-editing technique offers new way to model cancer

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Now, MIT researchers have found an alternative: They have shown that a gene-editing system called CRISPR can introduce cancer-causing mutations into the livers of adult mice, enabling scientists to screen these mutations much more quickly. In a study appearing in the Aug. …

RNA that regulates cell death identified

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Researchers from the University of São Paulo (USP) have identified an RNA known as INXS that, although containing no instructions for the production of a protein, modulates the action of an important gene in the process of apoptosis, or programmed cell death. …

New combination therapy developed for multiple myeloma

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While several drugs are effective against multiple myeloma, including the proteasome inhibitor bortezomib, multiple myeloma cells are often able to survive by increasing the production of a protein known as Mcl-1. Mcl-1 regulates a number of processes that promote cell survival and has been implicated in resistance to anti-myeloma drugs that were initially effective. However, a team of researchers led by Xin-Yan Pei, M.D., Ph.D., and Steven Grant, M.D., recently published the findings of a study in the journal PLoS ONE demonstrating that a novel drug combination both reduces Mcl-1 expression and disrupts its interactions with other proteins to effectively kill multiple myeloma cells. …

Colon has safety mechanism that restricts tumor formation

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The scientists have observed that the formation of an adenoma in the colon is accompanied by an increase in the production of a molecule called BMP (bone morphogenetic protein). …

Cancer: Treatment that prevents tumor metastasis identified in animal study

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The work by Professor Pierre Sonveaux’s team, at Université catholique de Louvain’s Institute of Experimental and Clinical Research (IREC), succeeded in pinpointing a family of pharmaceutical compounds whose action prevents the appearance of tumor metastasis. The researchers achieved this tour de force by studying the mitochondria in tumor cells. These organelles are considered as the cells’ power station…

Two new possible drug targets for triple negative breast cancer — ScienceDaily

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source : http://www.sciencedaily.com/releases/2014/05/140527114304.htm

Fighting cancer with dietary changes — ScienceDaily

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source : http://www.sciencedaily.com/releases/2014/05/140526101503.htm

Epigenetic mechanisms distinguishing stem cell function, blood cancer decoded — ScienceDaily

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source : http://www.sciencedaily.com/releases/2014/05/140509130044.htm