Tag Archives: journal

HPV associated with increased risk of HIV in men

The study, published online by the journal AIDS, was authored by Jennifer Smith, PhD, MPH, research associate professor with the Gillings School of Global Public Health and member of the UNC Lineberger Comprehensive Cancer Center, and Anne Rositch, PHD, MSPH, assistant professor with the University of Maryland School of Medicine. "These data from Kenya add to a mounting evidence showing a higher risk of HIV acquisition among individuals with genital HPV infections," said Smith. Men in the study with at least one occurrence of HPV infection faced double the risk of acquiring HIV, and those with three or more HPV infections had more than three times the risk of developing HIV. This pattern was consistent in both circumcised and uncircumcised men…

Study of human blood fluke parasites identifies drug resistance mutations

"This is a major advance," said Claudia Valentim, Ph.D., the primary author of the report, who worked at both institutions. "We were able to identify the critical gene by crossing resistant and sensitive worms in the laboratory and then analyzing the genomes of the progeny. This method is commonly used for fruit flies and other laboratory organisms, but has not previously been possible for schistosome parasites." "This really shows the utility of genome sequencing," says Anderson. "The schistosome genome was published in 2009…

Cancer treatment: A step towards personalized chronotherapy

An international study conducted on mice and coordinated by researchers from Inserm, CNRS and Universit Paris-Sud has paved the way towards personalized chronotherapy treatments. In an article published in the journal Cancer Research, the team has shown that the timing of optimal tolerance to irinotecan, a widely used anti-cancer drug, varies by 8 hours depending on the sex and genetic background of mice…

Cancer researchers translate new findings to enhance melanoma treatment

Translational researchers from UCLA’s Jonsson Comprehensive Cancer Center (JCCC) have published results of two back-to-back studies in the journal Cancer Discovery that provide critical insights into two key areas of how tumors resist BRAF inhibitors: the key cell-signaling pathways BRAF-mutant melanoma cells use to learn how to become resistant to inhibitor drugs, and how the limited focus of BRAF inhibitors allows melanoma cells to evolve and develop drug resistance. The studies were published online ahead of print on November 21, 2013…

Chemotherapy: When intestinal bacteria provide reinforcement

Results of this work are published in the journal Science on 22 November 2013. The intestinal microbiota is made up of 100,000 billion bacteria. It is a genuine organ, since the bacterial species that comprise it carry out functions crucial to our health, such as the elimination of substances that are foreign to the body (and potentially toxic), or keeping the pathogens that contaminate us at bay. …

Link between allergies, increased risk of blood cancers in women

Notably, the study did not find the same association in men, which suggests a possible gender-specific role in chronic stimulation of the immune system that may lead to the development of hematologic cancers. The findings are published online ahead of the December print issue of the American Journal of Hematology. "To the best of our knowledge, ours is the first study to suggest important gender differences in the association between allergies and hematologic malignancies," wrote first author Mazyar Shadman, M.D., M.P.H., a senior fellow in the Clinical Research Division at Fred Hutchinson Cancer Research Center. …

‘Undruggable’ mutation meets its match

Now, Howard Hughes Medical Institute (HHMI) researchers at the University of California, San Francisco have identified and exploited a newfound "Achilles heel" in K-Ras. The weak point is a newly discovered "pocket," or binding site, identified by HHMI investigator Kevan M. Shokat and colleagues. Shokat and his team have designed a chemical compound that fits inside this pocket and inhibits the normal activity of mutant K-Ras, but leaves the normal protein untouched…