Tag Archives: dlbcl

Drug-antibody pair has promising activity in non-Hodgkin lymphoma

The ongoing open-label phase 2 study presented at the American Society of Hematology (ASH) meeting was designed to test the activity of brentuximab vedotin (Adcetris) in relapsed or refractory non-Hodgkin lymphoma (NHL) including B-cell cancers such as diffuse large B cell lymphoma (DLBCL). The antibody-toxin compound has been approved for treatment of relapsed or refractory Hodgkin lymphoma and anaplastic T cell lymphoma, and its success prompted the trial in NHL, said Eric Jacobsen, MD, of Dana-Farber, senior author of the study. First author is Nancy Bartlett, MD, of Washington University School of Medicine. …

New evidence that aging tumor cells may be an effective cancer treatment

"Normally, this pathway is responsible for senescence and suppressing proliferation of B cells," said Hong Zhang, PhD, assistant professor of cell & developmental biology at UMMS and senior author of the study. "However, human DLBCL show low levels of Smurf2 expression; these low levels affect a pathway that encourages un-checked cell division and tumor growth. …

Aggressive lymphoma: Low doses of approved drug switches on pathway that allows chemotherapy to kill cancer

Researchers from Weill Cornell Medical College and NewYork-Presbyterian Hospital, who led the study published in Cancer Discovery, say their strategy has the potential to change the standard of care for patients with diffuse large B-cell lymphoma (DLBCL) — and possibly other kinds of tumors. The targeted drug they used, azacitidine, is designed to reawaken molecular mechanisms that typically trigger cell death but are switched off as cancer — including lymphoma — progresses. The research team discovered that pretreating aggressive lymphoma with azacitidine enables the death signal to turn back on when chemotherapy triggers it. In a proof-of-concept, Phase 3 study of 12 high-risk DLBCL patients led by Dr. …

Novel drug shuts down master protein key to lymphoma

In the journal Cell Reports, published today online, the scientists describe how the powerful master regulatory transcription factor Bcl6 regulates the genome, ensuring that aggressive lymphomas survive and thrive. They also show how the Bcl6 inhibitor, developed at Weill Cornell, effectively gums up the protein, stopping it from working…