Tag Archives: director

Zebrafish useful tool in prostate cancer stem cell study

Prostate cancers are suggested to contain self-renewing tumor stem cells that have the ability to grow uncontrollably and spread. Identified as tumor-initiating cells (TICs), research has shown that these cells are found to be resistant to standard chemotherapy. A desirable treatment strategy is to develop therapies that would effectively target the self-renewing capabilities of the TICs, which requires better identification of TICs themselves. Utilizing prostate cancer samples from patients diagnosed at the Cancer Institute of New Jersey between 2008 and 2012, Cancer Institute investigators used mouse and zebrafish models to identify the frequencies of TICs from each patient’s prostate cancer cells. …

Two-drug combination improves survival in pancreatic cancer

The new drug is set to become a reference in advanced pancreatic cancer treatment A multicentre phase III study, with centers participating from 11 countries in North America, Europe and Australia, shows that the drug combination nab-paclitaxel and gemcitabine is more effective in the treatment of patients with advanced pancreatic cancer than gemcitabine alone, which has been the standard treatment for these patients up until now. The clinical trial, sponsored by Celgene Corporation, involved 861 patients, half of whom were administered the nab-paclitaxel/gemcitabine combination, while the other half received gemcitabine alone. …

Promise for treating papillary thyroid cancer

R. Dadu and colleagues from M. D. Anderson Cancer Center, Houston, TX, will report on a series of patients with advanced metastatic PTC and the V600E BRAF mutation who were treated with the selective BRAF inhibitor vemurafenib in a poster presentation at the upcoming 83rd Annual Meeting of the American Thyroid Association, October 16-20, in San Juan, Puerto Rico…

Rising trend in genome mapping delivers targeted breast cancer treatment

Even more promising, clinical research trials at a few select institutions around the country, including Cleveland’s University Hospitals Case Medical Center Seidman Cancer Center, are part of a development in a rising trend toward targeted treatments as a result of genomic profiling of tumors. …

Less blood clot risk linked to estradiol than to Premarin pills

"Although oral estrogens are effective for managing menopause symptoms, not enough is known about the cardiovascular safety of different oral hormone therapy products relative to each other," said first author Nicholas L. Smith, PhD. He is a professor of epidemiology at the UW School of Public Health, the director of the Veterans Affairs (VA) Seattle Epidemiologic Research and Information Center (ERIC) at the VA Puget Sound Health Care System, and an affiliate investigator at Group Health Research Institute. To further understand the differences in risk, the researchers also measured clotting (coagulation) factors in the blood of women who did not develop a clot. …

New insights into the ribosome; important implications for disease

But in recent years, it has been demonstrated that the ribosome is far more than just a processing unit; indeed, current research points to an important role for this complex structure in actively regulating biological processes. Now, in a first-of-its-kind study that broadly examines the composition of the riboproteome, a scientific team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) reveals previously unappreciated components of the ribosome, uncovering a large and dynamic structure that, among other things, can be altered in cancer. Published in today’s on-line issue of the journal Cell Reports, the study additionally describes the development of an analytic platform that can be widely applied to numerous biological systems to highlight the functional roles of possible disease genes associated with the riboproteome. "A primary goal of our lab is to gain a better understanding of translation and its impact on cancer," explains senior author Pier Paolo Pandolfi, MD, PhD, Scientific Director of the Cancer Center at BIDMC and George C…

Broccoli to fight skin cancer?

A diet heavy in cruciferous vegetables, such as broccoli sprouts, has shown potential risk-reduction properties for colorectal, prostate and various other forms of cancer. Dr. Dickinson’s research currently focuses on how sulforaphane — a naturally occurring compound in broccoli with established chemopreventive properties — could possibly be used to help patients reduce their risk for skin cancer. What sets Dr. …

NIH, Lacks family reach understanding to share genomic data of HeLa cells

"Just like their matriarch, the Lacks family continues to have a significant impact on medical progress by providing access to an important scientific tool that researchers will use to study the cause and effect of many diseases with the goal of developing treatments," said NIH Director Francis S. Collins, M.D., Ph.D. In the Nature Comment, Dr. …