Tag Archives: development

Scientists find potential new clues for identifying breast cancer risk

Dr. David Gilley’s laboratory at the Indiana University School of Medicine in Indianapolis and Dr. Connie Eaves’ laboratory at the BC Cancer Agency’s Terry Fox Laboratory in Vancouver, Canada, collaborated to determine how telomeres are regulated in different types of normal breast cells. …

Michael Douglas’ interview: Can you get throat cancer from oral sex?

The Guardian newspaper published an interview with Michael Douglas on Sunday, in which the 68-year-old actor said his throat cancer hadn’t been caused by drinking or smoking – but by having oral sex. “Without wanting to get too specific, this particular cancer is caused by HPV, which actually comes about from cunnilingus,” Douglas told the British newspaper.  Douglas also went on to speculate that the stress of his son Cameron’s incarceration might have helped trigger the cancer as well. While a representative for Douglas maintains the actor did not specifically say oral sex was the cause of his cancer, the conversation still begs the question: Does having oral sex play a role in the development of oral cancer? While a connection between the two may seem bizarre, it is very possible that some oral cancers are the end result of intimate sexual contact. Rates of oral cancer – sometimes referred to as head and neck cancers – have been on the rise over the past decade.  While the main risk factors for oral cancers typically include drinking alcohol and smoking, around 25 percent of mouth and 35 percent of throat cancers are related to human papilloma virus (HPV) infection. “(HPV) is present within the fluids that are part of oral sexual behavior,” Dr. Marshall Posner, director of the head and neck oncology program at Mount Sinai Hospital in New York City, told FoxNews.com. “The vaginal fluids and semen will contain epithelial cells that have the virus on them and also free viral particles that can cause infection.” HPV cannot be transmitted through blood contact, but Posner said it may be possible to contract the virus from the direct contact of fluids through kissing. This can occur if an individual kisses someone who previously performed oral sex on someone else who had the virus. “If the virus is present in the oral pharynx and if it gets secreted in the saliva, then the saliva will contain potentially dangerous viral particles,” Posner said. There are more than 100 different types of HPV, and nearly everyone contracts some form of the virus in their youth.  Fortunately, the majority of HPV strains do not cause any symptoms, and in 90 percent of cases, the infection is naturally eradicated from the body within two years. However, some HPV types can cause genital warts, while others may lead to certain cancers in rare cases. HPV 16 and HPV 18 – which are sexually transmitted – are most closely associated with HPV-positive oropharyngeal cancer. According to Posner, 3 percent of adult males and 1 percent of adult females will have detectable HPV 16 in their saliva at any given moment in time.  However, just because HPV is detected in a sample of someone with oral cancer does not necessarily mean HPV caused the cancer.  According to the National Health Service in Britain, the virus becomes part of the pre-existing cancer cells’ genetic material, fostering the cells to grow. Oropharyngeal cancer symptoms include a lump in the back of the throat or mouth, pain in the ear or back of tongue, and difficulty swallowing. While the prognosis for HPV-negative oropharyngeal cancer is around 40 to 50 percent, the survival outcomes are generally better for HPV-positive cancers, ranging from 80 to 95 percent.  However, that prognosis is affected by drinking and smoking, which may have been a problem for Douglas. In the United States, HPV-related oropharyngeal cancer represents 60 percent of the total number of orapharyngeal cancer cases, which equal to about 15,000 per year.  Posner estimated that those cases will increase to 20,000 a year by the year 2015. While researchers cannot fully explain the rising rates of these cancers, one of the biggest risk factor for contracting HPV-positive oroharyngeal cancer includes having a high number of sexual partners, Posner said. “In smoking cigarettes and cancer, it doesn’t matter what brands you smoked, it matters how many you smoked,” Posner said.  “With HPV, it’s about the number of ‘brands’ you’ve been involved with. If you have numerous partners, you have a much higher risk of developing cancer. So (monogamous) people should go ahead and have the same intimate and personal relationship that they have with their partners and not be worried about it.” For those looking to protect themselves from contracting dangerous forms of HPV, practicing safe sex by using protection such as condoms and dental dams may help to diminish the spread of sexually transmitted diseases.  Posner also called for parents to get their children – including young boys –vaccinated against HPV. “I think people should make every effort to have children vaccinated, so I don’t have to treat this in the future,” Posner said.  I think it’s very important and to cure cancer we have to support research – it’s the best way we have to figure out how to cure this. Click to learn more about HPV from Mount Sinai Hospital.source : http://www.foxnews.com/health/2013/06/03/michael-douglass-reveal-can-get-throat-cancer-from-oral-sex/

New cancer drug shows promise for treating advanced melanoma

The results were presented at the 2013 meeting of the American Society of Clinical Oncology today in Chicago by Dr. Antoni Ribas, professor of medicine in the UCLA division of hematology-oncology, who led the research. Following Ribas’ presentation, the study was published online ahead of press in the New England Journal of Medicine. The results are from the first clinical trial of the drug lambrolizumab (MK3475), which was discovered and developed by Merck…

Novel class of drugs for prostate cancers

In men with advanced prostate cancer, growth of cancer cells depends on androgen receptor signaling, which is driven by androgens, such as testosterone. To thwart tumor growth, most patients with advanced prostate cancer receive drugs that block the production of androgen or block the receptor where the androgen binds. Unfortunately, such treatments invariably fail and patients die of prostate cancer with their androgen receptor signaling still active and still promoting tumor growth. In the new study, available online at Nature Communications, a team of researchers led by Dr. …

Pregnancy hormone may predict postpartum depression risk

Levels of a stress hormone released by the placenta could predict a woman's risk of developing postpartum depression, new research suggests. The new findings suggest that measuring levels of the hormone, called placental corticotropin-releasing hormone (pCRH), could one day help identify women who are prone to postpartum depression before they give birth. “Women who show high levels of this hormone prenatally are at increased risk,” said study co-author Laura Glynn, a psychologist at Chapman University in Orange, Calif. The study showed an association, not a cause-and-effect relationship, between pCRH levels and postpartum depression. Further research is needed to determine exactly how this link might work. The study was presented May 21 at the annual meeting of the American Psychiatric Association, and has not been published in a peer-reviewed journal. Placental clock The placenta, which lies within the uterus and provides nutrition to the baby, produces varying amounts of the hormone pCRH over the course of pregnancy, with a sharp rise shortly before birth. Scientists believe the hormone plays a role in timing when women deliver their babies. “It's been called the placental clock,” Glynn told LiveScience. Women who deliver prematurely, for instance, tend to show higher levels of pCRH than those who deliver at term. Depression link To understand how pCRH levels may be related to postpartum depression, Glynn and her colleagues measured hormone levels in the blood of 170 pregnant women at 15, 19, 25, 31 and 36 weeks of gestation. (Full-term pregnancies last 40 weeks.) The researchers also assessed the women's levels of depression at three and six months after giving birth. Women with high levels of pCRH around the middle of their pregnancies (at 25 weeks) were more likely to be depressed three months after giving birth, compared with women whose levels were lower at midpregnancy. The researchers didn't find a link between pCRH levels and depression at the six-month mark. Proactive treatment The findings could help identify women who are at risk of postpartum depression before they give birth so that health care professionals could intervene early. It can be hard for women struggling with new motherhood and depression to get help, but identifying at-risk women in the earlier stages of their pregnancies could make it easier for doctors to help. Its especially important to identify the risk early on because postpartum depression can have lasting effects. “Not only is mom suffering, but her suffering is going to influence the development of the infant in a pretty profound way,” Glynn said. Glynn isn't exactly sure why high pCRH levels might predict the risk of depression, but she said it could be because some women's hormonal systems take longer to return to their prepregnant states. The findings also suggest that postpartum depression that appears soon after birth may have different causes than depression that shows up later on. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/05/24/pregnancy-hormone-may-predict-postpartum-depression-risk/

Infantile myofibromatosis: First drug targets in childhood genetic tumor disorder

IM is an inheritied disorder that develops in infancy or even in utero and tumors continue to present throughout life. The tumors do not metastasize, but can grow large enough to invade the tissue surrounding them causing physical limitations, disfiguration, bone destruction, intestitinal obstruction, and even death. …

Study brings greater understanding of tumor growth mechanism

The study is published in Brain: A Journal of Neurology. Tumour suppressors exist in cells to prevent abnormal cell division in our bodies. The loss of a tumour suppressor called Merlin leads to tumours in many cell types within our nervous systems. There are two copies of a tumour suppressor, one on each chromosome that we inherit from our parents…

Brain makes call on which ear is used for cell phone

The study — to appear online in JAMA Otolaryngology-Head & Neck Surgery — shows a strong correlation between brain dominance and the ear used to listen to a cell phone. More than 70% of participants held their cell phone up to the ear on the same side as their dominant hand, the study finds. Left-brain dominant people — who account for about 95% of the population and have their speech and language center located on the left side of the brain — are more likely to use their right hand for writing and other everyday tasks. Likewise, the Henry Ford study reveals most left-brain dominant people also use the phone in their right ear, despite there being no perceived difference in their hearing in the left or right ear…