Antiangiogenic drugs are anticancer drugs designed to cut off the blood supply that brings tumors the nutrients they need to grow and survive, thereby starving and killing the tumor cells. …
Now adrenal cancer researchers at the University of Michigan Comprehensive Cancer Center are seeing the results of their laboratory studies translate to a clinical trial to test a potential new therapy in patients. Researchers Tom Kerppola, Ph.D., and Gary Hammer, M.D., Ph.D., collaborated to test a new compound, ATR-101, in cell lines and mice. …
Their study, published today in the Proceedings of the National Academy of Sciences (PNAS) suggests the compound, already shown to be safe for humans, may protect normal tissues during radiation therapy for cancer treatment and prevent or mitigate sickness caused by radiation exposure. The compound, known as DIM (3,3′-diindolylmethane), previously has been found to have cancer preventive properties. "DIM has been studied as a cancer prevention agent for years, but this is the first indication that DIM can also act as a radiation protector," says the study’s corresponding author, Eliot Rosen, MD, PhD, of Georgetown Lombardi Comprehensive Cancer Center. For the study, the researchers irradiated rats with lethal doses of gamma ray radiation…
"Our study investigated how resveratrol and radiotherapy inhibit the survival of melanoma cells," said Michael Nicholl, MD, assistant professor of surgery at the MU School of Medicine and surgical oncologist at Ellis Fischel Cancer Center in Columbia, Mo. "This work expands upon our previous success with resveratrol and radiation in prostate cancer. …
Govindsamy Vediyappan, assistant professor of biology, noticed that diabetic people in developing countries use a medicinal herb called Gymnema slyvestre to help control sugar levels. He decided to study the microbiological use of Gymnema slyvestre — a tropical vine plant found in India, China and Australia — to see if it could treat a common human fungal pathogen called Candida albicans. The investigation was successful on two levels: Vediyappan’s research team found the medicinal compound is both nontoxic and blocks the virulence properties of the fungus so that it is more treatable. The results are important for human health, biomedical applications and potential drug development. …
A diet heavy in cruciferous vegetables, such as broccoli sprouts, has shown potential risk-reduction properties for colorectal, prostate and various other forms of cancer. Dr. Dickinson’s research currently focuses on how sulforaphane — a naturally occurring compound in broccoli with established chemopreventive properties — could possibly be used to help patients reduce their risk for skin cancer. What sets Dr. …
Blocking this molecule, called TRPV4, greatly protects against the painful effects of sunburn. …
Prostate cancer is the second most common cancer and the second leading cause of cancer-related death among men in the United States. One treatment option for these patients is castration — the chemical or surgical removal of the testes — which reduces the production of the male sex hormone testosterone…