Next-generation sequencing has revolutionized functional genomics. These techniques are key to understanding the molecular mechanisms underlying cell function in healthy and diseased individuals and the development of diseases like cancer. Data from multiple experiments need to be integrated, but the growing number of data sets makes a thorough comparison and analysis of results challenging. …
Researchers at the USDA/ARS Children’s Nutrition Research Center at Baylor College of Medicine and Texas Children’s Hospital have now created a mouse model providing the first in vivo evidence that epigenetic alterations alone can cause cancer. Their report appears in the Journal of Clinical Investigation…
In the past, surgical treatment for liver metastases was not considered an option for most patients, as the disease typically spreads to other organs. However, advances in surgical techniques along with new systemic therapies have made existing therapies more effective and opened the door to new therapeutic approaches. “Although there has been a great deal of excitement about the new medical therapies, which are clearly enormous advances, those are still not the answers for everyone,” said lead investigator Mark Faries, MD, FACS, Director of the Donald L. …
A 65-year-old male patient with a history of chronic alcoholism complained of an odd, painless white growth over his tongue. Doctors at the Government Medical College in Latur, India were intrigued when they identified the hard white growth as a rare case of spindle cell carcinoma. Spindle cell carcinoma is an aggressive variant of squamous cell carcinoma. These tumors get their name from their distinctive spindle-shaped cells, readily detectable by immunohistochemistry…
The most widely used screening test for prostate cancer is currently the PSA test, which measures the blood’s level of PSA — a protein that is naturally produced by the prostate gland and is typically increased when cancer is present. However, it is widely recognized that PSA results can often indicate the possibility of prostate cancer when none is present. “The PSA test is based on the fact that men with higher levels of the PSA protein are more likely to have prostate cancer,” said William Catalona, MD, principal investigator on the Prostate Health Index clinical study and urologist at Northwestern Medicine and director of the Clinical Prostate Cancer Program at the Robert H. …
source : http://www.sciencedaily.com/releases/2014/07/140722091559.htm
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