Category Archives: SPOTLIGHT

Suspicions confirmed: Brain tumors in children have a common cause

The findings are published in the latest issue of the journal Nature Genetics. Brain cancer is the primary cause of cancer mortality in children. Even in cases when the cancer is cured, young patients suffer from the stress of a treatment that can be harmful to the developing brain. In a search for new target structures that would create more gentle treatments, cancer researchers are systematically analyzing all alterations in the genetic material of these tumors…

Novel nanoparticle delivers powerful RNA interference drugs

In a new paper appearing today online in the journal, ACS Medicinal Chemistry Letters, researchers at Sanford-Burnham Medical Research Institute have developed nanoparticles that appear to solve a big challenge in delivering the RNA molecules, called small interfering RNA, or siRNA, to the cells where they are needed. By synthesizing a nanoparticle that releases its siRNA cargo only after it enters targeted cells, Dr…

Aronia: The North American super berry with cancer fighting properties

While elderberry from Austria, acai from the Amazon, maqui from Patagonia and sea-buckthorn berry from Northern Asia have all made headlines as super berries packed with nutrition, a lesser known North American berry is gaining ground, poised to hit the nutritional spotlight as a world class super berry: Aronia. Commonly found wild in woodlands and swamps, aronia is also known as chokeberry, due to its astringent flavor. The berries come naturally in three colors – red, purple and black-purple. Aronia melanocarpa, the black-purple species, has a much deeper purple color than blueberries, which are also North American natives. The berry is now cultivated, and that cultivation is expanding in anticipation of the berry’s impending popularity. The deep purple color of Aronia melanocarpa has attracted a lot of scientific attention. Purple fruits by virtue of their color are rich in the category of antioxidants known as anthocyanins. These pigments demonstrate potent cell-protective properties, and are also anti-inflammatory, helping to reduce systemic inflammation – a key factor in the development of chronic diseases. But this is just the start of the benefits offered by aronia. Digging more into the compounds found in this native berry, scientists have found a number of more specific agents, including caffeic acid, cyanidin-3-galactoside, delphinidin, epicatechin, malvidin, and many more. You’ll likely never have to remember these names, but to health researchers, the presence of these compounds in aronia is big news. Combined, these specific agents in aronia are anti-bacterial, anti-viral, and anti-diabetic. They fight the formation of arterial plaque and lower serum cholesterol, and they protect the liver against a host of insults and toxins.  In our ever-increasingly diabetic society, aronia’s compounds help to lower blood sugar and improve the body’s own natural production of insulin. Several of the compounds in aronia are natural cancer fighters, and protect against the development of tumors of the bladder, breasts, colon, lungs, ovaries and skin. In addition, these compounds fight Crohn’s disease, inhibit HIV, reduce uncomfortable symptoms of PMS and fight herpes. Preliminary studies have also shown that aronia may prove helpful in slowing the growth of glioblastoma – a form of fatal brain cancer. Since the 1940s, aronia has been commercially cultivated in Russia, and since the 1950s, it has been a commercial crop in Europe. In 2009 the Midwest Aronia Association formed in Iowa to provide information and resources to farmers who wanted to get involved with commercial farming of this super berry. According to the association, members are now found in California, Illinois, Iowa, Michigan, Minnesota, Mississippi, Missouri, Nebraska, New York, North Dakota, South Dakota, Wisconsin and Ontario, Canada. In the world of berries, antioxidant activity is a major factor in the endless jockeying for position as top berry. Aronia has greater antioxidant activity than cranberry, blueberry, strawberry, cherry, pomegranate, goji and mangosteen. You can think of aronia as the King Kong of antioxidant berries. This awesome antioxidant power gives growers of the berry confidence that super-stardom for aronia is close at hand. Aronia berry products are already in the market, and some have received coveted USDA Organic certification – the highest standard of agriculture purity in effect today. Unlike strawberries and many other fruits, aronia is naturally pest-resistant and does not require the use of agricultural toxins. This spells good news for those who do not want unhealthy chemicals in their fruits. In the contest for ever healthier foods, aronia is surely a winner in the making. With science demonstrating significant benefits to health, farmers planting large acreage and the media increasingly boosting its fortunes, it’s only a short matter of time before aronia, the North American super berry, leaps to prominence in juices, jams, jellies and many other products.Chris Kilham is a medicine hunter who researches natural remedies all over the world, from the Amazon to Siberia. He teaches ethnobotany at the University of Massachusetts Amherst, where he is Explorer In Residence. Chris advises herbal, cosmetic and pharmaceutical companies and is a regular guest on radio and TV programs worldwide. His field research is largely sponsored by Naturex of Avignon, France. Read more at& MedicineHunter.com.source : http://www.foxnews.com/health/2013/06/07/aronia-north-american-super-berry-with-cancer-fighting-benefits/

Scientists find potential new clues for identifying breast cancer risk

Dr. David Gilley’s laboratory at the Indiana University School of Medicine in Indianapolis and Dr. Connie Eaves’ laboratory at the BC Cancer Agency’s Terry Fox Laboratory in Vancouver, Canada, collaborated to determine how telomeres are regulated in different types of normal breast cells. …

‘Junk DNA’ plays active role in cancer progression, researchers find

The researchers, led by Dr Cristina Tufarelli, in the School of Graduate Entry Medicine and Health Sciences, discovered that the presence of this faulty genetic element — known as chimeric transcript LCT13 — is associated with the switching off of a known tumour suppressor gene (known as TFPI-2) whose expression is required to prevent cancer invasion and metastasis. …

When it comes to cancer, information is power

Noreen asked me to fill in for her today.  Don't worry, she has actually been feeling better this past week.  She got to take a break from chemo, which always makes her feel better, and she learned her tumor markers dropped from 600 to 53!  We are very excited about that bit of news. The reason I am writing this week is because there has been a lot of attention given to the announcement by Angelina Jolie that she underwent a preventative double mastectomy with reconstruction when she learned she had the BRCA (BReast CAncer ) gene.   I, too, had the surgery after testing positive for the gene.  People, myself included, were stunned by Angelina's announcement.  When one of the most famous and arguably beautiful women in the world has a preventative mastectomy, it sheds a spotlight on the issue and reminds us that not even fame and fortune can save us from cancer.   Since Angelina “came out,” breast cancer advocates, doctors, news commentators and others have given their opinions on whether or not Angelina and other women with the breast cancer gene and/or breast cancer have made the “right” decision by having a double mastectomy. But there is no “right” or “wrong” in these situations.  No one wants a mastectomy . . . no one.  Women (and some men) choose the long, painful and disfiguring surgery to either remove cancer from their bodies or to try and prevent it when they have a greatly increased risk of getting breast cancer.    Angelina and I had an 87 percent chance of developing breast cancer.  Eighty-seven percent! You have all followed Noreen's blogs.  She is one of my closest friends.  When I compared having a mastectomy to what she has endured, for me, a mastectomy felt like the better option.   Still, the message I want to send is that surgery is not the only option for women who have the breast cancer gene or otherwise have an increased risk. The important thing is that you don't keep your head in the sand.  Information is power.  You should talk to your health care provider and determine whether you are at an increased risk.   If testing for the breast cancer gene is recommended, just remember your life won't change if you find out you have it; you just have more information so you can explore more options.   Surgery is just one option.  Women at high risk are also eligible for increased screenings, which could help “catch” cancer early and give you a fighting chance if you do develop the disease.   Like I said, there is no right or wrong answer, but when you have all of the information, you can determine what option is best for you.     Noreen will be back next week.  Until then, keep up with her on Facebook    Michelle McBride is the President of the Noreen Fraser Foundation.source : http://www.foxnews.com/health/2013/05/15/when-it-comes-to-cancer-information-is-power/

Review on aspirin to treat and prevent heart attacks and commentary on aspirin to prevent colorectal and other cancers

This update was published in the current issue of the American Journal of Medicine by Hennekens and James E. Dalen, M.D., M.P.H., dean emeritus, University of Arizona College of Medicine and executive director of the Weil Foundation. In a commentary published in Clinical Investigation, Hennekens and David J…

Gene offers clues to new treatments for a harmful blood clotting disorder

The research, which was led by Yanming Wang, a Penn State University associate professor of biochemistry and molecular biology, and Denisa Wagner, senior author with decades of research on thrombosis at the Boston Children’s Hospital and the Harvard University Medical School, will be published in in the Online Early Edition of the journal Proceedings of the National Academy of Sciences during the week ending 10 May 2013. The team’s new findings are an extension of previous research by Wang and other scientists. In earlier studies, Wang and his colleagues had revealed that a gene in mice called Pad4 (peptidylarginine deiminase 4) produces an enzyme that plays an important role in protecting the body from infection. The researchers discovered that cells with a functioning PAD4 enzyme are able to build around themselves a protective, bacteria-killing web that is dubbed a NET (neutrophil extracellular trap)…

Sales price of drugs you can guarantee a minimum it?

I sell a variety of anticancer drugs hospital than other hospitals or institutions about 20-50% lower prices, and we have some concessions to poverty reduction activities are organized. Hospital in our province and I can help a non-profit hospitals and old disabled units, the existence of economic difficulties for the patients we will give a… Read More »