Category Archives: Cancer Treatment

New medication treats drug-resistant prostate cancer in the laboratory

The results will be presented Monday at The Endocrine Society’s 95th Annual Meeting in San Francisco. "Our novel prostate cancer drug works by a unique mechanism of action," said study lead author Jeremy Jones, PhD, assistant professor of molecular pharmacology at City of Hope, Beckman Research Institute, in Duarte, CA. "Thus, it has the potential to treat cancers resistant to currently approved therapies." Prostate cancer is the second-leading cause of cancer death, after lung cancer, among men in the United States, according to the American Cancer Society. The disease affects about one out of every six men, and more than 29,000 will die of prostate cancer this year alone. …

‘Chase and run’ cell movement mechanism explains process of metastasis

Published in Nature Cell Biology, the new study focuses on the process that occurs when cancer cells interact with healthy cells in order to migrate around the body during metastasis. Scientists know that cancer cells recruit healthy cells and use them to travel long distances, but how this process takes place and how it could be controlled to design new therapies against cancer remains unknown. Now, using embryonic cells called ‘neural crest cells’ (which are similar to cancer cells in term of their invasive behaviour) and placode cells which are the precursors for cranial nerves (the equivalent to healthy cells) researchers at UCL have started to unravel this process. They have found that when neural crest cells are put next to placode cells they undergo a dramatic transformation and start ‘chasing’ the placode cells…

Osteoporosis drug stops growth of breast cancer cells, even in resistant tumors, study suggests

The findings, presented June 15, 2013, at the annual Endocrine Society meeting in San Francisco, indicate that the drug bazedoxifene packs a powerful one-two punch that not only prevents estrogen from fueling breast cancer cell growth, but also flags the estrogen receptor for destruction. "We found bazedoxifene binds to the estrogen receptor and interferes with its activity, but the surprising thing we then found was that it also degrades the receptor; it gets rid of it," said senior author Donald McDonnell, PhD, chair of Duke’s Department of Pharmacology and Cancer Biology. In animal and cell culture studies, the drug inhibited growth both in estrogen-dependent breast cancer cells and in cells that had developed resistance to the anti-estrogen tamoxifen and/or to the aromatase inhibitors, two of the most widely used types of drugs to prevent and treat estrogen-dependent breast cancer…

Most childhood cancer survivors have health problems in adulthood

Nearly all childhood cancer survivors have at least one chronic health condition by the time they reach middle age, a new study suggests. In the study, 95 percent of childhood cancer survivors had a chronic health problem such as hearing loss, heart valve abnormalities, lung problems, memory problems or new cancers by age 45. (For comparison, about 38 percent of adults in the general population who are ages 35 to 64 have at least one chronic health condition). While some cancer survivors in the study had no symptoms from these problems, about 80 percent had a life-threatening, serious or disabling condition, the study found. Considering that participants in the study were relatively young (the average age was 32), the prevalence of disorders typically associated with old age was particularly striking, researchers said. Those disorders include cataracts (15 percent), nerve pain (20 percent) and cognitive impairment (35 percent). These findings suggest that in some cases, cancer treatment may accelerate aging, the researchers said. The findings underscore the need for doctors to monitor childhood cancer survivors for conditions that could cause significant health problems if not detected early, the researchers said. Physicians should check for new cancers, heart disease and additional problems that can be improved with treatment, such as vision deficits. Childhood cancer survivors should be aware of the treatment they had when they were younger so that their doctors can order appropriate screening tests, said study researcher Kirsten Ness, of the St. Jude Children's Research Hospital in Memphis. Some survivors may be able to reduce their risk of certain health conditions. For instance, cancer survivors who are at risk for high blood pressure or blood fat levels may be able to reduce their risk of these conditions by following a healthy lifestyle (eating healthy foods, exercising and not smoking), Ness said. Childhood cancer, adult health Some cancer treatments may increase the risk of adult health problems because the treatments damage normal tissue in addition to cancer cells, Ness said. Most previous studies of childhood cancer survivors asked participants about their health problems, but did not evaluate them with a medical exam. These studies thus likely underestimated the prevalence of chronic conditions. In the new study, 1,713 childhood cancer survivors underwent a battery of medical tests such as measurements of blood pressure, blood glucose levels, resting heart rate, heart electrical activity and thyroid function. Some participants, who were considered “at risk” for certain conditions because of the type of cancer treatment they had received in childhood, were also screened with more specific tests, such as mammograms to detect breast cancer among women who underwent chest radiation. In these “at risk” survivors, lung problems were diagnosed in 65 percent of patients, hormone problems involving the hypothalamus and pituitary gland were diagnosed in 61 percent, heart abnormalities were diagnosed in 56 percent, and cognitive impairment, including memory problems, was diagnosed in 48 percent. Participants were survivors of childhood leukemia, lymphoma and tumors of the brain, bone and other organs. Future research Not all of the health problems detected by the tests were noticeable in everyday life. For instance, although tests showed that leukemia survivors who had received radiation experienced impaired memory, their ability to hold a job and carry out daily activities was not affected. Future research will be needed to examine how this problem, and other problems that don't show symptoms, progress over time, the researchers said. Additional studies should attempt to determine which factors predispose childhood cancer survivors to the conditions seen in the study, the researchers said. The study was published June 12 in the Journal of the American Medical Association. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/06/11/most-childhood-cancer-survivors-have-health-problems-in-adulthood/

Very high prevalence of chronic health conditions among adult survivors of childhood cancer

"Curative therapy for pediatric malignancies has produced a growing population of adults formerly treated for childhood cancer who are at risk for health problems that appear to increase with aging. The prevalence of cancer-related toxic effects that are systematically ascertained through formal clinical assessments has not been well studied…

Men with prostate cancer should eat healthy vegetable fats, study suggests

By substituting healthy vegetable fats — such as olive and canola oils, nuts, seeds and avocados — for animal fats and carbohydrates, men with the disease had a markedly lower risk of developing lethal prostate cancer and dying from other causes, according to the study. The research, involving nearly 4,600 men with non-metastatic prostate cancer, could help with the development of dietary guidelines for men with the disease. While prostate cancer affects millions of men around the world, little is known about the relationship between patients’ diets following their diagnosis and progression of the disease…

Normal molecular pathway affected in poor-prognosis childhood leukemia identified

Leukemia often occurs due to chromosomal translocations, which are broken chromosomes that cause blood cells to grow uncontrollably. One gene that is involved in chromosomal translocations found at high frequency in childhood leukemia is the MLL1 (Mixed Lineage Leukemia 1) gene. Conventional chemotherapy is very ineffective at curing patients with this translocation, in contrast to other types of childhood leukemia, which are relatively curable. …

Nontoxic cancer therapy proves effective against metastatic cancer

The study, "The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer," was published online today in PLOS ONE. Led by Dominic D’Agostino, PhD, principal investigator in the Department of Molecular Pharmacology and Physiology at the USF Health Morsani College of Medicine, the research shows the effects of combining two nontoxic adjuvant cancer therapies, the ketogenic diet and hyperbaric oxygen therapy, in a mouse model of late-stage, metastatic cancer…