Category Archives: Cancer Treatment

New solution in detecting breast-cancer related lymphedema

Now, a team of researchers led by Mei R. Fu, PhD, RN, ACNS-BC, associate professor of Chronic Disease Management at the New York University College of Nursing (NYUCN), offers supporting evidence for using Bioelectrical Impedance Analysis (BIA) ratios to assess Lymphedema. The study, "L-DEX Ratio in Detecting Breast Cancer-Related Lymphedema: Reliability, Sensitivity, and Specificity," published in Lymphology, argues because the low frequency electronic current cannot travel through cell membranes, it provides a direct measure of lymph fluid outside the cells. This allows for a more accurate assessment of lymphedema using a Lymphedema Index named L-Dex ratio. …

Balloon mis-positioning during prostate cancer treatment could affect success of radiation delivery

"Use of a balloon allows you to stabilize the anatomy. But what we show is that imprecision with balloon placement could reduce radiation dose coverage over the intended area," says Moyed Miften, PhD, FAAPM, investigator at the CU Cancer Center and chief physicist at the University of Colorado School of Medicine Department of Radiation Oncology. Specifically, Miften and colleagues including Bernard Jones, Gregory Gan, and Brian Kavanagh studied the technique known as stereotactic body radiation, in which powerful, precisely-targeted radiation is delivered only to cancerous areas of the prostate with the hope of killing tumor tissue. An endorectal balloon is needed to hold the prostate in place while this high dose is delivered…

Working towards personalized cancer treatment

"We all have a unique composition of hereditary variants of genes that affects how both our body and the tumor react to cancer treatment," Ola Myklebost tells us. He is Professor of Molecular Biology in the Department of Biosciences at the University of Oslo, and also holds a post at the Institute for Cancer Research at Oslo University Hospital. Professor Myklebost has now received a grant of NOK 75 million from the Research Council of Norway to develop the idea for next generation cancer treatment — personalized cancer therapy, directed specifically towards the various mutation faults in cancerous tumors…

Scientists find ‘missing link’ in important tumor suppression mechanism

The team, led by Professor Yoshiaki Ito of CSI Singapore, showed that RUNX3 is a major component in a well-established tumor suppression mechanism involving p53, a tumor suppressor protein that regulates cell proliferation and prevent cancer. In addition, the research team also demonstrated that RUNX3 plays a pivotal role in preventing early tumor formation. Although the current study focused on lung cancer, the results help to explain the development of other types of human cancers. These novel findings were published in leading scientific journal Cancer Cell on 11 November 2013. …

Oxygen levels in tumors affect response to treatment

tumors with lower levels of oxygen — known as hypoxia — often respond less well to radiation therapy. There are several agents that can be given to patients before radiotherapy to reduce hypoxia, but these are not given as standard. Being able to measure how well-oxygenated an individual’s tumor is would give doctors a valuable way of identifying which patients might benefit from treatment with hypoxia reducing agents before radiotherapy. Hypoxia has previously been investigated by looking at the expression of certain genes, and Manchester researchers have come up with a genetic profile for tumors that should indicate the overall level of oxygenation…

Potential drug target to nip cancer in the bud

The research was conducted by Dr Dmitry Bulavin and his team at A*STAR’s Institute of Molecular and Cell Biology (IMCB), with their findings published in the 14 October 2013 issue of the scientific journal, Cancer Cell. The team discovered that Wip1 phosphatase is a key factor that causes point mutations to sprout in human cancers. These types of mutations stem from errors that are made during DNA replication in the body, causing one base-pair in the DNA sequence to be altered. These mutations can cause cancers to take root, or to become resilient to treatment. …