Category Archives: Cancer Treatment

Treatment for overactive bladder and irritable bowel syndrome advanced through pioneering research — ScienceDaily

The new study, published in The FASEB Journal, has found that this clock activity in turn regulates the cycle of all cells in the body. The team of researchers also discovered that the local biological clock and its control are weakened in aging bladders, demonstrating the importance of the clock in bladder physiology and aging. While currently much is known about the central biological clock, little is known about the peripheral clocks in the body. This latest research challenges the long-held view that the central clock of the brain controls all the peripheral clocks in other parts of the body and that these in turn control the down-stream receptor molecules which generate specific cell activities, such as contraction, secretion and metabolism…

Novel gene predicts both breast cancer relapse, response to chemotherapy

Despite advancements in cancer treatment, breast cancer remains the most common cancer among Singapore women. Thirty percent of early breast cancer patients in the world experience relapse due to metastasis, or the spread of cancer cells to other organs in the body. Some patients also do not respond well to chemotherapy…

RNA combination therapy for lung cancer offers promise for personalized medicine

This week in the journal Proceedings of the National Academy of Sciences, researchers at the Koch Institute for Integrative Cancer Research at MIT now report that they have successfully delivered small RNA therapies in a clinically relevant mouse model of lung cancer to slow and shrink tumor growth. Their research offers promise for personalized RNA combination therapies to improve therapeutic response. …

Guidelines can predict early menopause in child cancer survivors, giving hope for fertility

The criteria — developed in Edinburgh — will help to select which girls should be offered the opportunity to freeze some tissue from their ovaries for use in the future. Doctors are optimistic that the frozen tissue could one day help young cancer survivors to have children of their own…

NSAIDs may lower breast cancer recurrence rate in overweight, obese women — ScienceDaily

“Our studies suggest that limiting inflammatory signaling may be an effective, less toxic approach to altering the cancer-promoting effects of obesity and improving patient response to hormone therapy,” said Linda A. deGraffenried, PhD, associate professor of nutritional sciences at The University of Texas in Austin. The study found that women whose body mass index (BMI) was greater than 30 and had estrogen receptor alpha (ERα)-positive breast cancer had a 52 percent lower rate of recurrence and a 28-month delay in time to recurrence if they were taking aspirin or other NSAIDs. “These results suggest that NSAIDs may improve response to hormone therapy, thereby allowing more women to remain on hormone therapy rather than needing to change to chemotherapy and deal with the associated side effects and complications,” said deGraffenried…

NSAIDs may lower breast cancer recurrence rate in overweight, obese women

“Our studies suggest that limiting inflammatory signaling may be an effective, less toxic approach to altering the cancer-promoting effects of obesity and improving patient response to hormone therapy,” said Linda A. deGraffenried, PhD, associate professor of nutritional sciences at The University of Texas in Austin. The study found that women whose body mass index (BMI) was greater than 30 and had estrogen receptor alpha (ERα)-positive breast cancer had a 52 percent lower rate of recurrence and a 28-month delay in time to recurrence if they were taking aspirin or other NSAIDs. “These results suggest that NSAIDs may improve response to hormone therapy, thereby allowing more women to remain on hormone therapy rather than needing to change to chemotherapy and deal with the associated side effects and complications,” said deGraffenried. …

Prostate cancer prevention trial identifies men mostly likely to undergo challenging study procedure — ScienceDaily

The Prostate Cancer Prevention Trial was a randomized, double-blind, placebo-controlled trial which tested the efficacy of finasteride, a drug used for prostate cancer prevention. This study was conducted by SWOG — a cancer research cooperative group that designs and conducts multidisciplinary clinical trials. …

New analysis reveals tumor weaknesses in epigenetics

Analyzing these modifications can provide important clues to the type of tumor a patient has, and how it will respond to different drugs. For example, patients with glioblastoma, a type of brain tumor, respond well to a certain class of drugs known as alkylating agents if the DNA-repair gene MGMT is silenced by epigenetic modification…