Childhood cancer survivors face different health-care challenges and are more susceptible to dying earlier than the general population. They have a higher risk of second cancers, heart disease, body weight disorders and psychosocial problems…
Professor David Beech, of the School of Medicine at the University of Leeds, who led the research, said: “Blood vessel networks are not already pre-constructed but emerge rather like a river system. Vessels do not develop until the blood is already flowing and they are created in response to the amount of flow. This gene, Piezo1, provides the instructions for sensors that tell the body that blood is flowing correctly and gives the signal to form new vessel structures. …
Writing in the August 11, 2014 issue of Developmental Cell, David A. …
“We and others have found that Lin28b — a gene that is normally turned on in fetal but not adult tissues — is expressed in several childhood cancers, including neuroblastoma, Wilms’ tumor and hepatoblastoma, a type of cancer that accounts for nearly 80 percent of all liver tumors in children,” said Dr. Hao Zhu, a principal investigator at CRI, and Assistant Professor of Pediatrics and Internal Medicine at UT Southwestern Medical Center. “In our study, we found that overproduction of Lin28b specifically causes hepatoblastoma, while blocking Lin28b impairs the cancer’s growth…
The protein mTOR regulates cell growth and metabolism and thus plays a key role in the development of human disorders. In the cell, this regulatory protein is found in two structurally and functionally distinct protein complexes called mTORC1 and mTORC2. …
Dr. Jobe’s findings were published online in Cancer, a journal of the American Cancer Society…
“A person’s gut microbiome is the collection of all the bacteria in their gut,” said Patrick D. Schloss, PhD, associate professor in the Department of Microbiology and Immunology at the University of Michigan in Ann Arbor. …
The American Cancer Society predicts that this year in the United States, more than 12,100 women will be diagnosed with cervical cancer, and roughly 4,220 women will die of the disease. Newer Pap tests and HPV screening more accurately identify pre-cancerous cellular changes that potentially develop into cervical cancer…
Treatments involving neck manipulation may be associated with stroke, though it cannot be said with certainty that neck manipulation causes strokes, according to a new scientific statement published in the American Heart Association’s journal Stroke. Cervical artery dissection (CD) is a small tear in the layers of artery walls in the neck. It can result in ischemic stroke if a blood clot forms after a trivial or major trauma in the neck and later causes blockage of a blood vessel in the brain…
There are three predominant cancers that affect women — breast, ovarian and womb cancer. Of the three, ovarian cancer is of the greatest concern as it is usually diagnosed only at an advanced stage due to the absence of clear early warning symptoms. Successful treatment is difficult at this late stage, resulting in high mortality rates. Ovarian cancer has increased in prevalence in Singapore as well as other developed countries recently…