Radical dose radiotherapy of esophageal cancer

By | March 21, 2012

Dose radical radiotherapy of esophageal cancer, esophageal cancer is generally believed that conventional radiotherapy dose irradiation 1 day, each 1.8-2.0Gy, 5 times a week, total dose 60-70Gy/6-8 week, less than 50Gy effect poor, may not be enough to kill esophageal squamous cell carcinoma, the efficacy of doses greater than 70Gy is not good.
Studies suggest that in conventional radiotherapy, the survival of cancer stem cells may lead to accelerated repopulation of conventional fractionated radiotherapy failures. So that the accelerated hyperfractionated radiotherapy can overcome tumor cell repopulation during radiotherapy to improve the outcome.
Esophageal dose radical radiotherapy, the current conventional fractionated radiotherapy for esophageal cancer with hyperfractionated radiation therapy and after full-course accelerated hyperfractionated radiotherapy. Hyperfractionated accelerated radiation therapy or a daily exposure to 2 or 3 times lower than conventional fraction dose divided doses, close to or slightly lower than the conventional total dose divided doses, with a total course of treatment shorter than conventional radiotherapy, but the acute reaction than conventional radiotherapy weight, The late response to light. Hyperfractionated accelerated radiotherapy of esophageal cancer have been many reports at home and abroad, but there is no uniform standard, is further study. Esophageal full results of accelerated hyperfractionated radiotherapy is superior to conventional fractionated radiotherapy has not been reported.
Dose radical radiotherapy of esophageal cancer, late-course accelerated hyperfractionated radiotherapy, that is, the total radiation therapy started 2 / 3 (40Gy or so) with conventional fractionated irradiation, after 1 / 3 instead accelerated hyperfractionated radiotherapy dose, compared with conventional fractionation ratio, the split, the number of total course of treatment shorter, the same total dose. Reported that the late-course accelerated hyperfractionated radiotherapy is superior to conventional fractionated radiotherapy.

Leave a Reply

Your email address will not be published. Required fields are marked *