Chemical treatment of chronic lymphatic leukemia

By | October 20, 2011

Chemical treatment of chronic lymphocytic leukemia
1. A single chemotherapy
(1), chlorambucil (CB134S): is a burnt agent. Drug of choice for the treatment of CLL, the effective rate of 70% or more, usually O. OS_O. 1mg / (kg.d) until disease control, to maintain treatment, the dose in the O. 04_0. OSmg / (kg d) until remission . Side effects are nausea, vomiting, leukopenia, or thrombocytopenia.
Pull Bin monophosphate fluoride nap (fludarabine monophosphate) mechanism is an interference adenosine nucleotide metabolism, half of progressive CML effective, according to 25_30mg / (m2.d), 5 days, intravenous infusion, every 4 weeks of intermittent Repeat course of treatment. DNA between the CTC to help: the powerful adenosine deaminase inhibitors. ATP rapidly metabolized in the body deoxy adenosine, inhibition of DNA synthesis. Treatment of CLL number_30% 20% efficiency. Dose 4mg/m2, intravenous, 1 week, 3 weeks after 1 every other week, also 5mg/m2, a month with 3 consecutive days. Side effects are nausea, vomiting, neuropathy, liver and kidney function impairment, mild bone marrow suppression. DNA in addition to chlorine treatment of gland is also effective with his back to CLL. Cyclophosphamide cool plastic (CTX): is more commonly used drugs, can also be used on the CB1348 is invalid. Common dose 2_5mg / (kg.d). Corticosteroids: prednisone 30_40mg / d and melted agents often use the combined solution autoimmune or immune thrombocytopenia poor effectively.
(2) : COP (CTX VCR Pred)CHOP , M2 Chemical treatment of chronic lymphatic leukemia (2) combination chemotherapy: COP program (CTX, VCR, Pred) and CHOP program, the disease can also try multiple myeloma M2 program.

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