Various histological types of lung ultrastructure

By | March 31, 2012

Various histological types of lung ultrastructure and ultrastructural characteristics of lung cancer treatment and prognosis of lung cancer and other aspects of relationships, some researchers conducted a preliminary study. Some foreign scholars have found features with squamous cell differentiation of small cell lung cancer patients, the treatment may actually survive 5 years more than 25%. Domestic scholars small cell lung cancer by immunohistochemistry and ultrastructural studies on the ultrastructure of neurosecretory granules that were polymorphic and has the characteristics of cases of squamous cell differentiation, with a longer survival time. However, small cell lung cancer and large cell lung ultrastructure of research, the results found for clinical treatment and prognosis of patients with significant ultrastructural features.
Various histological types of lung ultrastructure 1. Squamous cell carcinoma: squamous cell carcinoma cell ultrastructure mainly as a bridge between the grains (desmosome) connection, and can see the tension (tonofilament, referred to as the tension of wire) attached to the intracytoplasmic There were scattered actin bundle tension. Well differentiated, the desmosome and the number of multi-tension wire, a good development, poorly differentiated, the tension wire and the bridge less grains, and the development is not sufficient.
Under electron microscope, shows a small number of squamous cell carcinoma to the phenomenon of neuroendocrine differentiation, which can be seen in squamous cell cancer cells with neuroendocrine granules, visible even in a cancer cell neuroendocrine granules tension tow and the phenomenon of coexistence.
Various histological types of lung ultrastructure 2. Adenocarcinoma: Adenocarcinoma of the ultrastructural features of the main cavity between cancer cells and (or) cell within the cavity, the surface microvilli; connections between cells may have complex , finger-like protrusion connection, a highly developed Golgi apparatus, a secretory granule or liquid particles Bo exist. As with squamous cell carcinoma, adenocarcinoma, may also be accompanied by a small number of neuroendocrine differentiation structure, that is, within the cancer see cancer cells with neuroendocrine granules, or cancer cells, see the presence of neuroendocrine granules. Accompanied by a small number of neuroendocrine differentiation in adenocarcinoma of the phenomenon can be.
Various histological types of lung ultrastructure 3. Adenosquamous carcinoma: electron microscope, the cancer within the same time with the ultrastructural features of squamous cell carcinoma and adenocarcinoma, even in the same cancer cells. Squamous cells and glandular cells in the proportion of ingredients in different cases or different areas of the same tumor is inconsistent. Leaves can be expressed as the degree of differentiation of the two components are good or are poorly differentiated, of which seven are good and the other ingredients a component of several forms of poor differentiation.
Various histological types of lung ultrastructure 4. Neuroendocrine carcinoma of the lung neuroendocrine carcinoma (neuroendocrine carci11011 called include typical carcinoid, atypical carcinoid, small cell carcinoma and large cell neuroendocrine carcinoma of four types of distressed manner. electron microscope, these four types of neuroendocrine carcinoma of the co-possessed (I characteristic structure: a large number seen in the cytoplasm membrane surrounding the dense core granules (cIt ~ nse-core granules) or neurosecretory granules (neurosecretory granules) . (II different histological types of cancer cell cytoplasm of the number of dense core granules, the shape, size difference.
In addition, other structures, such as cytoplasmic processes, cytoplasmic compartment, non-desmosome connections between cells, basement membrane, rough endoplasmic reticulum and mitochondria structure, its degree of development between the number of different types are not exactly the same.

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