Cachexia and cytokines

By | March 26, 2012

In recent years, cachexia and cytokines, many studies suggest that endogenous cytokines in cancer anorexia, disease quality plays a very important role. Data shows that tumor necrosis factor, interleukin-1, IL-6, -interferon and leukocyte inhibitory factor in cancer cachexia play an important role. In addition to these cytokines cards, some studies have also found that some of the tumor metabolic factors may act directly on muscle and adipose tissue, bone and other Confucian target organs, resulting in abnormal metabolism.
Cachexia and cytokines: Fat Metabolism Factors
Studies have found that tumor products could lead to fat in adipose tissue decomposition, and to isolate these substances, so called lipid metabolic factors are a class of heat-stable and can withstand the proteolytic enzymes in the skin substances, such substances can be activated Gan Youlan vinegar caused lipolysis activity. Animal experiments have shown, LMF can lead to weight loss, fat pad weight declined 85%, plasma triglyceride increased 43% enzyme concentration, and thus it is related with the mobilization of body fat. Wong acid such material available in the case of consumption does not affect the body weight decreased significantly. In vitro studies found that fish oil polyunsaturated fatty acids can inhibit the production of tumor LMF.
Cachexia and cytokines: protein metabolic factors
Recent studies have found that rats cachexia separable from a 24,000 molecular weight glycoprotein, known as protein metabolism factor (PMF). The study found that, PMF and the animal was related cachexia. PMF animal weight loss can be inhibited by HU body. Clinically significant in patients with cachexia can be detected in urine such as the 24,000 molecular weight glycoprotein, but not in patients with cachexia was undetectable. In addition, other causes such as burns, multiple trauma, surgery, infection, weight loss in the urine did not detect the substance. Therefore, PMF is considered cancer cachexia is a special factor.

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