The performance of gastric precancerous lesions

By | April 3, 2012

The performance of precancerous lesions is the tendency some have malignant lesions, such lesions, which if not treated may develop gastric cancer. Precancerous lesions, including precancerous state and pre-cancerous lesions, the concept of the former Department of bed Wu II, the latter pathology concepts.
Gastric precancerous lesions of the performance 1. gastric precancerous state:
(1) chronic atrophic gastritis: chronic atrophic gastritis and gastric cancer incidence was significantly positively related to follow-up from the cases that occurred in atrophic gastric inflammation were present about 10%. Chronic atrophic gastritis may start to come from the development of superficial gastritis, intestinal metaplasia and further, anaplastic and malignant transformation. Some people think that fasting in patients with chronic atrophic gastritis, gastric free acid content decreased, the number of bacteria, nitrate-reducing bacteria increased the detection rate of intestinal metaplasia and gastric intestinal viscosity related. Chronic gastritis, gastric atrophy intestinal metaplasia dysplasia, gastric cancer, the evolution model has been endorsed by scholars.
(2) pernicious anemia: pernicious anemia, 10% of patients with gastric cancer, gastric cancer was normal population 5_10 times.
(3), gastric polyp: adenoma villous polyps into account although the proportion of non-gastric polyps, cancer rate of 15% -40%. Greater than 2cm in diameter were higher cancer rates. Hyperplastic polyps more common, then cancer was only 1%.
(4) remnant gastric cancer: benign lesions occurred in the remnant stomach after child cancer called gastric stump cancer. More common in benign diseases of the stomach or duodenum for gastric most are in addition more than 10 years after gastric remnant cancer took place. Japanese scholars then proposed radical surgery for gastric cancer more than 5 years occurred in the remnant stomach cancer are also included in the second remnant stomach cancer. Billrothn anastomosis than after Billroth I type of gastric cancer is more, the card contents duodenum gastric reflux to the residual cancerous is to promote an important factor in gastric cancer incidence rate of 2.16% residual __2.5%, similar to foreign reports .
As a special remnant gastric precancerous state has already started attracting increasing attention, but large differences in its meaning, Zhang Tianze that after 3 years of benign gastric diseases, gastric cancer occurred after 5 years of remnant stomach can be called the residual gastric cancer.
(5), benign gastric ulcer: benign gastric ulcer incidence of cancer reported each different. According to statistics of pathology, accounting for about 5%. Now that the disease itself is not a stain of gastric pre-cancerous state. The edge of anger War is likely to occur on your mucous membranes of intestinal metaplasia and malignant transformation.
(6) take great disease mucosa folds (Menetrier disease): loss of serum protein by a huge gastric mucosa, hypoproteinemia and clinical edema, about 10% of cancer.
The performance of gastric precancerous lesions 2. Precancerous gastric residence:
(1) intestinal metaplasia: is inherent in the stomach mucosa (including the pyloric glands and gastric glands, glands responsible for the door) into the small intestine (or colon) epithelial cells of the phenomenon, skin mucosal dysplasia. The predilection sites of lesions as the pyloric antrum and lesser curvature, in particular, pyloric glands and gastric glands of the transitional body of the Ministry, the lesion gradually increased with age. Generally divided into the small intestine and large intestine type of intestinal metaplasia type two kinds of small intestinal mucosa with intestinal-type features, well differentiated, with large intestinal characteristics of large, immature cells, is considered prone to cancer. Histochemical studies have shown that intestinal metaplasia of the gastric mucosa and gastric cancer, and its shares have a high degree of skin enzyme activity, metaplasia of gastric mucosa adhesive skin without enzyme inactive.
(2) Gastric epithelial dysplasia: also known as atypical hyperplasia, refers to the structure of gastric mucosa and epithelial deviate from the normal state, there has been some degree of atypia. Though not with malignant features, but with cell atypia, abnormal differentiation of mucosal structural disorder and three pathological features. Pathology can be divided into 3 dysplastic, that type of intestinal metaplasia, regenerative and adenoma, adenomatous hyperplasia which more closely with gastric cancer. Generally believed that moderate and severe dysplasia should be followed up, when its not easy to distinguish gastric cancer treatment when feasible child.

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