Special type of lung cancer – BAC

By | March 29, 2012

Special type of lung cancer – BAC, BAC is a special type of lung cancer, there are strict diagnostic criteria, specific morphology, differential diagnosis, clinical stage and prognosis has its own characteristics.
Special type of lung cancer – BAC (I) BAC diagnostic criteria: a. cancer not infiltrating interstitial, vascular, and pleura, which is (tJIHAC the gold standard; Once cancer was invasive growth, even if the cancer tissue, BAC concave structure, should a diagnosis of mixed BAC; b. small bronchoscopy or percutaneous biopsy of the lung biopsy tissue, although the histological features with the BAC, he diagnosed as BAC. because the final diagnosis should be removed by comprehensive set of samples is called, ruled out the BAC carcinoma invasion to clear diagnosis BAC; c. small nodules, do not easily diagnosed as BAC. because such a small tumor nodules, large memory from atypical adenomatous hyperplasia. with 2-3 grade branches of the nipple complex, the classification is the nipple. because of such morphology with BAC, the rest of the tumor invasive growth. In short, the BAC specimens, should be more drawn producer, In addition to the possibility of invasive growth.
Special type of lung cancer – BAC (2) HAC interstitial infiltration (BAC stromal invasion) is the structure of cancer cells with a BAC in the fibrous connective tissue (including interstitial and pleural) samples were acinar, solid nest-like growth , with the growth and collagen of fibrous tissue, with atypical cells produce or not produce mucus. HAC was invasive growth (invasive growth), including: through the pleura, lymphatic invasion, or metastasis.
Special type of lung cancer – BAC (3) JBAC clinical stage and prognosis: the majority are single BAC nodules, other types of cancer so well. If the single nodular type, nodular diameter of less than 2cm, surgical cure. And if a multi-nodular and diffuse infiltrative type, as both the late prognosis.
Special type of lung cancer – BAC (4) and solid adenocarcinoma with mucus (solid adenocarcinoma with mucin) histological features: solid adenocarcinoma is poorly differentiated adenocarcinoma. In solid cancer among groups may have a small amount of fibrous stroma. Cancer cells vary in size, shape varies; membrane rich cytoplasm, were eosinophilic or clear, and easy to see that cancer cells secrete fluid Bo; nuclear differentiation, the majority of vacuolization, prominent nucleoli, mitotic activity.
Special type of lung cancer – BAC (5) differential diagnosis: solid and poorly differentiated adenocarcinoma group should be in the diagnosis of cancer, large cell carcinoma, squamous cell differentiation: poorly differentiated squamous cell carcinoma of lung agglomerate structure, no keratin pearls, keratinized cells was not obvious, a few droplets of mucus containing cells, which form similar to the structure and solid adenocarcinoma. Identification of two points: a. solid peripheral lung adenocarcinoma were located, and poorly differentiated squamous cell carcinoma were located in the hilar Department; b. solid cancer cells with more fluid Mongolia, large drops of mucus, and poorly differentiated squamous cell carcinoma with moving fluid less accidentally discovered, fine droplets of mucus; c. layered solid-like structure was not cancer, lack of keratinized cells, and poorly differentiated squamous cell carcinoma of the nest was layered like structure, can be found in keratinocytes; d . real lack of inter-bridge between gonadal cells, poorly differentiated squamous cell easy to find the bridge; e. staining, such as mucus card red and PAS (by enzymatic digestion) staining, solid adenocarcinoma can be found in mucus and mucus droplets Lake And I saw a small number of poorly differentiated carcinoma cells move within the micro-droplets; f. electron microscopy, solid adenocarcinoma cells were Clara cells and alveolar epithelial cells; poorly differentiated carcinoma, the tension can be found in rich and mature fibrils different levels of desmosomes and connections.
large cell carcinoma: large cell undifferentiated carcinoma of the lung cancer is highly malignant. Mass for the solid cancer, a few cancer cells may contain mucus, and solid adenocarcinoma similar; identify key points: a. the solid and the liquid contained in adenocarcinoma and large cell carcinoma cells is far more easy see; b. large cell carcinoma is highly malignant undifferentiated carcinoma, so the cell atypia and tumor necrosis more evident than in solid adenocarcinoma; c. electron microscopy: large cell carcinoma were squamous cell carcinoma can be differentiated, while the solid cancer showed epithelial differentiation; the former has the tension of the original fibers and immature desmosomes, while the latter only the glandular-like structures, cells with abundant microvilli and straw liquid particles, well-developed endoplasmic reticulum and Golgi apparatus.

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