Pathophysiological manifestations of gastric cancer after surgery

By | April 2, 2012

Gastric resection caused by damage to the anatomy and function can often cause digestion, absorption, reasons:
(1) the pathophysiological manifestations of gastric cancer after surgery, the stomach volume smaller or no stomach to reduce food intake, reduced pepsin commanded loss, and poor iron absorption.
(2) food through the gastrointestinal non-physical structure and ways to make food through faster, mixed with digestive enzymes is not sufficient, another intestinal mucosa or home, resulting in malabsorption.
(3) stimulation of gastric secretion of duodenal gastrin loss or damage area. Secretin secretion cells were mainly distributed in the antrum and duodenum, in order to stimulate the gastric mucosa caused by food, gastrin secretion affect the secretion of hydrochloric acid solution with the membrane. Hormone secreting cells in the casting solution to promote mainly in the duodenum, the hydrochloric acid can stimulate a good way to promote the secretion of membrane enzymes and thus affect the membrane fluid, bile and bicarbonate secretion Li. There clinical anorexia or loss of appetite, indigestion, diarrhea and other symptoms.
(4) perigastric organs, nerves and other complications caused by removal, such as joint extended resection can lead to diabetes, the body and tail membranes are widely removed lymph nodes, distressed by the removal of plants can cause biliary function and intestinal motility disorder, disaster postoperative gallbladder , gallstone disease, diarrhea, abdominal distension syndrome. Gastrectomy complications occurred more commonly described here focus on several complications.
1. Dumping syndrome points early and late dumping syndrome, the former more common.
(1) causes: not yet entirely clear, but reconstruction after gastrectomy is an important factor. Bi-type reconstruction after 20%, about 15% after completion of ceremony. The smaller the residual stomach, the more prone, more severe. After total gastrectomy the incidence of dumping syndrome in most patients after about 3 times.
(2) methods of prevention: the pathophysiological manifestations of gastric cancer after surgery, the general principle is radical gastrectomy, gastrointestinal tract, as far as possible to complete type reconstruction. Distal subtotal gastrectomy, in addition to cancer in the pyloric and duodenal invasion round or outside, try the line on the end of the remnant stomach and duodenum anastomosis; proximal subtotal gastrectomy or total gastrectomy should be performed esophagus and remnant stomach (or duodenum) jejunal interposition operation. Set between the popular and easy way to be simplified.

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