Interventional therapy for liver cancer

By | October 8, 2011

Interventional therapy for liver cancer
Interventional treatment of liver cancer are the following methods:
(1) Chemotherapy: Chemotherapy is a concentration of forces attack the tumor treatment, ie, after the arterial catheter, the drug injected directly into the liver locally. It is the peripheral arterial catheter delivered through the hepatic artery after drug injection through the catheter directly to the lesions on the liver. With traditional intravenous administration (infusion) compared to its lower systemic toxicity; the same time, the use of selective arterial infusion may increase the liver local drug concentration. Dosage does not increase in the case of drug concentrations within the tumor tissue than normal tissue drug concentration within the high-5_20 times, thus effectively improving the therapeutic effect.
(2) Transcatheter embolization:
In our battle with cancer, in addition to concentrating a superior force attack, there is another strategy, that is, cut off the enemy's food channel, so that the loss of the enemy combat capability. Transcatheter embolization is the treatment strategy used, it is a catheter into the hepatic artery, by contrast find the nutrient vessels of the tumor, transcatheter infusion embolization agent, blocking the tumor blood vessels, to block the tumor blood supply and nutrition purposes . Its principle is this: the normal tissues and organs to only feeding arteries and draining veins, the blood from the artery into the tissue, tissue from the venous outflow. Different with the general organization of the liver, it is not only like other organizations, have their own feeding arteries and draining veins (ie, hepatic artery and hepatic veins), it also has a portal supply of nutrition. That is, accept the hepatic artery and hepatic portal vein blood supply; which accounted for 25% of the hepatic artery, portal vein blood 75%; liver cancer is different, it's blood supply 95% _100% from the hepatic artery. After hepatic artery embolization, liver blood supply more than 90% reduction, while the normal liver tissue blood flow decreased by only 30% — 40%. Therefore, if only the arterial blood supply to the tumor injection of embolic agents, can cause cancer tissue necrosis, but little effect on normal liver tissue. Currently, for unresectable hepatocellular carcinoma, transcatheter arterial chemoembolization (TACE) has become the preferred non-surgical therapy.
Interventional treatment of hepatocellular carcinoma (3) intervention by the portal vein:
We have just mentioned, the liver has a dual blood supply. In some patients, the tumor blood supply in addition to be, there is a branch of the portal vein to provide nutrition for it, in this case, in order to achieve better therapeutic effect, in addition to that we described above, hepatic artery chemoembolization, can also by percutaneous, catheter infusion into the portal vein chemotherapy and embolic agents. Chemotherapy drugs in low-voltage / low portal vein flow velocity, continuously, more sustained exposure of tumor cells play a role in cancer. This approach especially from other parts of the tumor metastasized to the liver is better.
(1) Early small hepatocellular carcinoma : the use of superselective hepatic artery catheterization can be only 1 mm in diameter to the liver artery catheter, for chemoembolization. Then underwent surgical resection is currently the preferred method.
(2) Where the treatment of inoperable advanced hepatocellular carcinoma (including primary liver cancer and metastatic liver cancer), as long as no contraindications are suitable as intervention. Intervention can also be used for preoperative diagnosis, provide the basis for the operation.
Interventional treatment of hepatocellular carcinoma (3) underwent interventional treatment of liver cancer not only inhibit micrometastasis, played the role of relapse prevention, but also to early detection of recurrence after surgery and residual tumor, to facilitate timely treatment. For liver cancer recurrence after surgery, interventional therapy prolong survival.

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