Gene diagnosis in the Diagnosis of Tumors

By | March 28, 2012

Gene diagnosis in the Diagnosis of Tumors 1. Early diagnosis of cancer oncogenes, cancer genes and their gene products has become a tumor marker. Gene mutations and abnormal expression of tumor genetic markers, as reflected in the pre-cancerous cell changes in start-up phase, it is for the early diagnosis of clinical monitoring. Such as the use of pancreatic duct fluid samples collected in the membrane, or from percutaneous needle biopsy or draw objects pancreas were K-ras point mutation analysis, can be used for early diagnosis of adenocarcinoma film. The prostate specific membrane antigen mRA marked (PSM), using gene diagnosis by searching the free circulation of micro cancer cell present, early diagnosis of prostate cancer. Has been confirmed in 51 different tumor types are present in the p53 gene mutation. In the colon cancer cases, p53 mutations occur about 70%, 50% of lung cancer. Breast cancer is 40%. Lymphatic system, blood system cancer tumors and also have high mutation rate. Therefore, esophageal cancer, gastric cancer and lung cancer was detected in exfoliated cells of p53 point mutation, has been the clinical diagnosis of cancer, prognosis and treatment that a new way.
Gene diagnosis in the Diagnosis of Tumors 2. Genetic screening such as conducting something called breast cancer -1 (BRCA-1) gene defect screening, for those due to genetic defects and easy for women with breast cancer is important. Family history of breast cancer for women, should always be examined to ensure early detection and early treatment.
Gene diagnosis in the Diagnosis of Tumors 3. Tumor prognosis tumor gene mutations, amplification and overexpression of such changes often associated with cancer prognosis, such as p53 gene mutation and breast, liver, colon and other tumors prognosis, PCNA, Ki67 and gastrointestinal stromal tumors, laryngeal cancer, malignant ovarian tumor, osteosarcoma, breast cancer, lung cancer and nasopharyngeal cancer and other tumors prognosis. Found that, from the molecular level to determine the biological behavior and prognosis of tumors with high accuracy.
Gene diagnosis in the Diagnosis of Tumors 4. Find the molecular target for the implementation of the first molecular targeted therapy to be by immunohistochemistry (lHC) and fluorescence in situ hybridization (FISH) and other cancer development and at different times, different genes may be involved different variations, and changes in gene and gene signaling between the sensitivity of the tumor is closely related to clinical treatment, if the tumor at the molecular level to provide indicators of genetic changes, the predictability of the tumor and treatment of individual will serve as guidance.

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