Gastric cancer metastasis

By | April 24, 2012

The transfer of gastric cancer , gastric cancer , mainly in the early stages of diffusion transfer within the stomach when the stomach teaching one or several films after the occurrence of cancer, cancer cell proliferation and development continue to direct the surrounding tissue and infiltration of adjacent organs or the cancer cells along the wine Pakistan tubes, blood vessels to the lymph nodes and distant organ metastasis. The proliferation of gastric cancer metastasis and features the following ways:
(A) direct infiltration
Direct invasion of cancer cells proliferation in the stomach with the main form of advanced gastric cancer can be passed through the stomach wall violations of the surrounding organs and organizations to the greater omentum most common, followed by liver, membranes, esophagus and transverse colon and so on. The way a direct invasion of block infiltration, diffuse infiltration and nested infiltration. However, in advanced gastric cancer , especially in comparison with advanced stomach cancer, not just a case of infiltration the same way. Massive infiltration by groups such as cases, and in some parts may have nested infiltration; to infiltration-based nested case, when cell differentiation is low, there may also be diffuse infiltration of the phenomenon.
(B) hematogenous metastasis
Often occur with advanced gastric cancer metastasis. Because the gastric lamina propria, submucosal and subserosal rich blood and lymph vessels. In addition to the process of tumor proliferation and destruction of lymphatic spread along the lymphatic metastasis, but also bound to break some local infiltration of veins and capillaries, the cancer cells or tumor thrombus to enter the bloodstream and is transported to other parts of the body and dirty device, the formation of distant organ metastasis. The approach is generally considered with the blood of cancer cells through the right atrium and right ventricle to reach the lung capillary network in the lungs is blocked and continuous proliferation of the formation of lung metastases. Gastric cancer cells in their blood may be the first to reach the liver via the portal vein within the capillary network, the proliferation in the liver to the formation of liver metastases. Therefore, lung, blood, liver metastasis of gastric cancer are the predilection sites, and often with multiple metastases. In addition to the transfer to the liver, lungs outside the metastasis of gastric cancer as soon as the blood can also be transferred to the bone marrow, skin, adrenal gland and other parts of the body.
Gastric cancer metastasis, (c) spread along the lymphatic
In addition to direct infiltration of tumor cells, but also to spread along the lymphatic channels. Layers exist in the stomach because the lymphatic network, in particular, and subserosa submucosal lymphatic vessels, especially rich in lymphatic spread so as to provide the conditions for the transfer. Lymphatic spread along two ways, namely, the continuity of continuous proliferation and non-proliferation.
Continuous proliferation of cancer cells is carried out of the proliferation of lymphatic vessels along the lymphatic lumen continuously spread to their respective nodes, up to a certain distance or reach the draining lymph nodes. Infiltration seen in this way, the growth of gastric cancer nested in the peritumoral submucosa or subserosa lymphatic lumen filled with a large number of solid tumor thrombus. Non-continuous diffusion loss to lymphatic cancer, cancer cells do not form a continuous cord, but more scattered floating or walk in the lymphatic lumen, lymphatic sinus from the planktonic state still continues to spread. Such diffusion is found or a diffuse infiltration of poorly differentiated adenocarcinoma of mucinous cell carcinoma growth.
Diffusion of the two is not in isolation, particularly in the proliferation of lymphatic continuity, sometimes only a certain distance, and then off to lymphatic cancer, the second way you can spread metastasis. Lymph node metastasis, lymphatic drainage according to the order number, from near and far, Deep. But can still transfer in leaps and bounds, that is when the transfer has not yet appeared near lymph nodes and distant lymph node metastasis of gastric cancer has been found.
Gastric cancer metastasis, (d) peritoneal metastasis and female genital
When the tumor invasion to serosa or invasion into the peritoneum, with the stomach and intestines and other organs of mutual friction, so that cancer cells or other organs in the peritoneal serosal surface of the planting of the transfer, that is peritoneal seeding. In cancer invasion to serosa or peritoneal seeding, because gravity causes the cancer cells easier to sink the peritoneal cavity into the pelvic cavity, the lacuna in the rectum, bladder or rectum occurred in plant lacunae uterine metastases. The transfer of female genital mutilation, first, ovarian metastasis, and more common both ovaries at the same time transfer. On transfer to ovarian cancer is not entirely clear the way, someone considered to be upstream or lymph node metastasis to the ovaries of blood, and some cancer cells that are implanted ovulation injury results. Followed by uterine cancer metastasis, suggesting that the first may be due to gastric cancer involving the lymph nodes or abdominal aorta below the total regret, Confucianism outside the lymph nodes, the pelvic lymphatic drainage blocked, resulting in lymphatic siltation, caused by retrograde lymphatic metastasis by the cancer cells to reach the cervix.
Diffusion transfer of the above are not isolated, especially hematogenous metastasis, the spread of gastric cancer is only one way, it not easy to completely separate lymph node metastasis. Such as gastric cancer, when the superior mesenteric or portal lymph nodes metastasis, the cancer cells can invade the portal vein, then to transfer into the blood lymphatic metastasis.


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