With chronic myeloid leukemia and chronic CLL is most common, the incidence of CML in the various age groups are higher in men than women and increased gradually with age, the incidence of very low before the age of 25, 50-59 peak CLL rare before the age of 30, the incidence rate increased significantly after the age of 50 and higher in men than women.
Features and diagnosis of chronic leukemia (1) chronic myeloid leukemia
Referred to as chronic myeloid leukemia CML is a pluripotent stem cell origin of neoplastic proliferative diseases, and its main feature is a significant increase in granulocytes, spleen was enlarged, the vast majority of the pH with a relatively specific marker chromosome, the course more slowly, Most of the acute changes and death.
The disease can occur all ages but is most commonly middle-aged. Early symptoms of multiple significant, increase in accidental discovery of neutropenia or splenomegaly was diagnosed. Apart from patients with fever, weight loss and fatigue symptoms may be caused by splenomegaly oppression gastrointestinal loss of appetite, falling left upper quadrant pain and other gastrointestinal symptoms. Almost all advanced cases of splenomegaly, or even fill the whole abdominal pelvic infiltration, hard, smooth surface. Inflammation around the spleen or splenic embolization complications of leukemia is more common than the other. About 40% of the patients had hepatomegaly about 75% of the patients had sternal tenderness, but enlarged lymph nodes and skin, eyes and bone invasion is rare, unless the patients have a tendency to rapid change. /L ; -> 200x l0 9 /L , When the WBC> 60x l0 9 / L can have two bites of retinal vein expansion, thickening or hemorrhage and nodules with exudate; – white base> 200x l0 9 / L white blood cells can occur when the disease can lead to stagnation center marks Khan The system bleeding, priapism, and even bone marrow necrosis.
Natural history of chronic myeloid leukemia can be divided into chronic phase and accelerated phase. Most patients diagnosed in the chronic phase can be obtained after a period of chronic disease entered the accelerated phase, when several clinical symptoms are obvious. Blast phase chronic myeloid leukemia is acute leukemia into the process, the Department of the majority of the performance of end-stage CML. CML in chronic phase can occur at any stage of clinical manifestations of acute leukemia and other similar.
Features and diagnosis of chronic leukemia (2) chronic lymphocytic leukemia
Chronic lymphocytic leukemia is caused by a group of non-lymphocyte immune activity, and its long survival, proliferation is slow, gradual accumulation and infiltration of bone marrow, blood, lymph nodes and various organs, eventually leading to hematopoietic failure. According to the different cell types can be divided into T cells and B cells in two types of the disease more common in old age n with congenital and acquired immune deficiency history of this disease easily. Typical clinical manifestations of chronic lymphocytic leukemia as lymphadenopathy, usually soft, and do not adhesions; often enlarged spleen; fatigue, weight loss, abdominal distension, anorexia is a common symptom. Some patients may have bone pain, regret, more performance for the dull pain, pain, or sternal tenderness. Sometimes even for routine blood examination revealed lymphocytosis and confirmed.
Features and diagnosis of chronic leukemia, when found more signs and symptoms of chronic leukemia, do not be careless, to the hospital immediately, and check the blood and bone marrow were excluded or confirmed, if necessary, with other relevant checks.
- IS STERNAL TENDERNESS SEEN IN CLL OR CML
- leukemia bone pain in sternum