Breast cancer prevention, (a) etiology prevention
That for breast cancer etiology and primary prevention measures taken. At present the cause of breast cancer is not very clear, but there are some risk factors for breast cancer, we can reduce the level of exposure risk factors to achieve the purpose of preventing breast cancer.
1. Endogenous estrogen
Found that artificial menopause can reduce the risk of breast cancer age and frequency of delivery and breast cancer risk related to the age of 20 before the first full-term risk of women is not producing women or> = 35-year-old full-term women half. Menarche age and a certain relationship between the occurrence of breast cancer, 11 years old or younger women with menstrual risk of breast cancer than women after the age of 14, 20% higher. Multiple birth factors may interfere with these risk factors. However, in women with familial breast cancer in these phenomena is not obvious. Therefore, interference by multiple pregnancy or hormone to regulate to prevent premature or early menopause effects, but for familial breast cancer is invalid. Human milk feeding can also reduce the risk of breast cancer.
2. Genetic
BRCA1 and BRCA2 have been clear to carry mutations will increase breast cancer risk to life. Estimated BRCAI family risk of breast cancer was 65%, BRCA2 families was 45%. Other genes and non-genetic factors may affect the BRCA genes, but it is still unclear. BRCA2 mutations carry BRCAI and young women the risk of breast cancer than other women, especially BRCAI mutation. Both have ovarian cancer, breast cancer risk of familial breast cancer was significantly higher than the only breast cancer families.
3. Abortion
The risk of breast cancer may be related, but there is not enough evidence.
4. Environmental factors
Occupation, environment, the impact of chemotherapy on breast cancer thing, little evidence. Possible chemical substances are organic chloride compounds. Ionizing radiation increases the incidence of breast cancer, especially for adolescent women at higher risk.
5. Diet and vitamin
Low fat diet breast cancer through hormonal mechanisms of risk. Fruits and vegetables may reduce the risk of breast cancer related. Also play a role of micronutrients, such as Hu Luoka factors, folic acid, vitamin A, vitamin C
6. Primary prevention of chemical intervention
Fenwei A plastic (a vitamin A analogues) may be able to reduce the carcinogenic effects. Use of tamoxifen in hormone intervention can reduce estrogen receptor positive breast cancer incidence, but the clinical side effects and impact the quality of life, there is no widely used. Endogenous sex hormones by reducing the method (to maintain an ideal body weight, postmenopausal women should be low in fat intake, moderate exercise such as young women), could reduce the incidence of breast cancer worthy of study.
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