Cancer patients because of loss of function caused by mutations in p53 gene and the formation of many types of human cancer-related. To treat the defect and induce apoptosis of tumor cells, has established a variety of wild-type p53 gene carrying adenovirus.Tumor suppressor gene therapy, at the beginning of the study, through the appropriate tumor cell lines and animal model system later proved that these pathways for malignant glioma and effectiveness of breast cancer treatment.
Tumor suppressor gene therapy, in some cases, wild-type p53 gene carrying adenovirus vector with a certain immune genes, such as lL-2 or with some cytotoxic drugs such as doxorubicin in combination, effect more pronounced. Detection of these vectors for lung cancer, head cancer, neck cancer and liver cancer clinical trials in progress. Another expression of proapoptotic proteins such as Fas ligand and caspase-8 because of the use of carrier vehicle production methods difficult and limited. However, the tumor suppressor gene therapy expression of the recently constructed gene CrmA syndrome virus serpm cell lines have provided a good production and exploration of the characteristics of these viral vectors way to port.