Variant of large cell carcinoma – basal cell carcinoma: large cell carcinoma of the cancer nest week was significantly palisading. Lung large cell carcinoma is a variant, relatively rare.
Variant of large cell carcinoma – basal cell carcinoma 1) the naked eye: tumors occur in the proximal bronchi. Cavity to the bronchial tumor was often meat-like or papillary growth, accompanied by wall infiltration. Tumor size of 1-6cm.
Variant of large cell carcinoma – basal cell carcinoma 2) Light microscopy: large cell carcinoma, basal cell carcinoma associated with the form of performance, that is lobulated, cable, like, cancer nests pericytes palisading. Cancer cells compared with the same shape, cube-shaped or spindle-shaped, cytoplasmic scarce. Moderately stained the nuclear chromatin was finely granular, most cancer cells but not nucleoli, mitotic easy to see 15-44 / 10HPF. Common type of acne (comedo tyPe) or lobular central coagulation (centrilohular coagulative) necrosis. But not within cancer cells and the intracellular bridge keratosis phenomenon. 50% of cases seen in situ lesions.
Variant of large cell carcinoma – basal cell carcinoma 3) electron microscopy: cells seen in the tension of the original fiber, visible desmosomes between cells (differentiation of the squamous epithelium), or micro-adenoid structure (to the adenoid differentiation), but not seen neuroendocrine granules.
Variant of large cell carcinoma – basal cell carcinoma 4) immunohistochemistry: cancer cells to low molecular weight cytokeratin (especially the CKS "CK6 and CK19) showed a consistent positive, but on the polymer protractor protein (such as CKI0, CKII and CK4) marked as negative.
Variant of large cell carcinoma – basal cell carcinoma 5) differential diagnosis
basaloid squamous cell carcinoma (hasaloid-squamous carcinoma): is a variant of squamous cell carcinoma type. Carcinoma histologically seen in cancer tissues was focal squamous differentiation of the features, such as intercellular bridges and (or) cell keratosis, or even the appearance of keratin pearls, but mainly composed of basaloid cells (> 50%).
small cell lung cancer (SCLC): SCLC neuroendocrine cells with clear morphological characteristics of tumors, such as organ-like structure, rosettes are the two most characteristic structure. The mitotic SCLC is more common. Immunohistochemistry and (or) electron microscopy, will also help to distinguish these two tumors. This type of poor prognosis and 5-year survival rate was 10% -15%.