Typical carcinoid tumors account for most of the lung carcinoid tumors account for 75% -90%, carcinoid, a low-grade neuroendocrine lung tumors. Survival rate was 95% -100%, the old year survival rate was 92.4%. The site of clinical symptoms and treatment of cancer tumors secrete hormones quality and quantity.
General description of typical carcinoid (1) pathological features of typical carcinoid:
In a typical carcinoid tissue, there may be focal cancer cell nest or spindle-shaped cells rich in cytoplasm with eosinophilic granules, deeply stained nucleus is relatively small, similar to the thyroid gland schuette ear cells (Hiirtvhvles cell). Cytoplasm of a minority class of cells clear, as clear cell carcinoid tumor. Carcinoid tumors are usually less matrix, mainly rich in blood vessels around the cancer nests, but some cancer, bone and cartilage matrix appear metaplasia, with dense fibrosis and calcification. Amyloid deposition in the tumor stroma are not uncommon. Some classes can produce mucous cells, tumor cells showed the cytoplasm of signet ring-like or contain melanin, the brain showed a return to the nuclear shape.
General description of typical carcinoid (2) Special staining:
Argyrophil carcinoid tissues were stained cell cytoplasm generally found addicted to tablets. Do net fiber dyeing, the lack of network fiber between cancer cells.
General description of typical carcinoid (3) immunohistochemistry:
Cancer cells were positive for cytokeratin. The labeled antibody with the nerve, such as network element particles A (CgA), synaptophysin (synaptophysin) and so the number of positive cells in the typical carcinoid and more diffuse, strong expression.
(4) electron microscopy:
Main features: a large number of nerve cell cytoplasm of the endocrine state and the size of the pieces have some variation, most were round or oval, the average particle size of 120 wind particles outer diameter of about 200 nmo a unit membrane parcels, particles as small as dense core of high electron density in the core and the unit membrane between the narrow space.
(5) DNA Analysis:
Most of the typical carcinoid diploid, but 32% of the non-aneuploid for whole day).
General description of typical carcinoid (6) Molecular Biology examination:
P53 gene mutations in non-typical carcinoid, P53 protein expression without the breeze. Rb element missing, no mutation was found. Apoptotic genes (bax) and antiapoptotic no abnormal changes.