Early esophageal cancer seen under the microscope type

By | March 24, 2012

Most of the early esophageal squamous cell carcinoma in situ or early invasive carcinoma, according to the endoscopic findings can be divided into 3.
Early esophageal cancer seen under the microscope, type 1. On the skin cancer or carcinoma in situ
Full-thickness epithelial cancer cells, cancer cells vary in size, or were pleomorphic, disordered polar disappear. Nuclear larger and vary in size, thickening of chromatin, mitotic common basement membrane integrity. According to the degree of differentiation of carcinoma in situ, can be divided into well differentiated (large cell carcinoma) and poor differentiation (small cell carcinoma) of the two types.
(1) well differentiated carcinoma in situ. Although the whole layer of epithelial cells in cancerous, but some of the more mature cells, cells large, were polygonal or round, large cytoplasm, nuclear round, small. Sometimes the nuclear vacuolization, the more the more obvious near-surface, while the cancer cells near the basal layer, the mostly undifferentiated basal cells.
(2) poor differentiation of carcinoma in situ. Layer of epithelial cells in all disorder, normal levels disappear, the cancer cells more consistent shape, cell size is small, oval or spindle-shaped nucleus often has, nuclear large and small, dark staining, mitotic common, but the basement membrane integrity.
The degree of differentiation of carcinoma in situ, even in the same specimens can be seen in the same field of vision. Poorly differentiated carcinoma in situ in the epithelium and sometimes cancer cells can appear well differentiated group, even bead keratosis.
Early esophageal cancer seen under the microscope, type 2. mucosal carcinoma in situ or invasive means of most Fu cancer cells of esophageal carcinoma in situ group, a breakthrough was cord-like basement membrane or mass, down to students up to the inherent invasive membrane or muscularis mucosa but not through the muscularis mucosa. General scope of the small, hard to find the naked eye.
Early esophageal cancer seen under the microscope, type 3. Submucosal carcinoma or early invasive
Carcinoma in situ of the basement membrane break down the cell population through the muscularis mucosa into the submucosa, but not involving the muscle, and no regional lymph node metastasis. Generally larger size of such lesions, a wider scope.
Development from early invasive carcinoma in situ, the tumor infiltrating the basement membrane was often exceeded in many invasive growth. Differentiation of cancer cells significantly correlated with the infiltration of dollars, the majority of stromal invasion of cancer cells to a mature nest phenomenon, and the depth of invasion and lymph node metastasis is a clear relationship.

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