In a study released Monday in the Annals of Internal Medicine, Tosteson and colleagues, including lead author Brian Sprague, MD, provide evidence on the benefits and harms of adding ultrasound to breast cancer screening for women who have had a negative mammogram and also have dense breasts. …
The identification of patients with high-risk breast cancer is key to knowing whether a patient will require only the removal of the tumor by surgery or whether if she will need additional chemotherapy to make sure the removal of breast cancer cells. Currently, known genetic mutations and expression patterns are determined, but the puzzle of the genetics of the disease remains a large unfinished part…
Using a method called CEL-Seq that can spy on the activity of every gene within a cell at once, Technion Associate Professor Itai Yanai and his colleagues now provide compelling evidence that the layer called the endoderm evolved first, followed by the ectoderm layer and finally the mesoderm layer. Yanai has other big plans for CEL-Seq. “We applied this unbelievably powerful tool to figuring out the evolution of the germ layers, a 19th century problem, but it will also be useful in things like cutting-edge cancer research as well,” he said. …
The results have just been published in the scientific journal Nature Communications. Chromosome segregation Recently there has been a lot of interest in understanding the chromosome segregation process and the impact of the protein BubR1…
“I’m not saying that people with metastatic breast cancer shouldn’t eat turkey during the holidays, but triple-negative breast cancer appears to have found a way to process tryptophan more quickly, equipping cancer cells to survive while in circulation, which allows them to metastasize,” says Thomas Rogers, the paper’s first author and PhD candidate in the laboratory of CU Cancer Center investigator, Jennifer Richer, PhD. When healthy cells become detached from the foundation on which they grow, they are programmed to undergo cell death through a process known as anoikis (“without a home” in Greek). This means that in order to metastasize, cancer cells have to evade anoikis — they have to survive while in suspension, unattached from a foundation. …
“It is widely thought amongst the clinical community that there is no association between family history and development of glioma. Because we know very little about the contributing genetic factors, when cases occur in two or more family members, it is viewed as coincidental,” said Dr…
An analysis of randomized trials demonstrated that patients with early-stage breast cancer who are treated with breast-conserving surgery and adjuvant whole-breast irradiation have improved survival and a lower risk of tumor recurrence compared to patients who are not treated with radiation therapy. Patients are commonly treated with CF-WBI; however, several recent randomized trials[2-5] have confirmed that patients treated with HF-WBI have similar disease-free and overall survival rates as those treated with CF-WBI. CF-WBI delivers a total dose of 45-50 Gy in 25-28 daily fractions of 1.8-2.0 Gy over five to six weeks, while HF-WBI uses a shorter treatment course and a lower total dose and number of fractions, delivering a total dose of 39-42.5 Gy in 13-16 daily fractions of 2.5-3.2 Gy over three to five weeks. …
Medulloblastoma is the most common brain tumor in children, and its treatment remains inefficient. The work of a team of researchers led by Luca Tiberi and Pierre Vanderhaeghen (Universit� libre de Bruxelles (ULB), WELBIO, IRIBHM and ULB Neuroscience Institute (UNI)) opens new perspectives on the diagnosis and treatment of these brain tumors…
The variation in ERAP1 can be detected by genetic testing which, if available, could lead to people becoming aware of the risk of the condition earlier. Ankylosing Spondylitis is a chronic inflammatory disease which mainly affects joints in the spine. In severe cases, it can eventually cause complete fusion and rigidity of the spine, called “Bamboo spine.” It tends to first develop in teenagers and young adults with most cases first starting in people aged 20-30…
In a world-first the researchers were able to show that changes in the isotopic composition of zinc, which can be detected in a person’s breast tissue, could make it possible to identify a ‘biomarker’ (a measurable indicator) of early breast cancer. …