Tag Archives: program

Ovarian cancer discovery deepens knowledge of survival outcomes

The research, led by Dong-Joo (Ellen) Cheon, PhD, found that the 10-gene biomarker panel may identify the aggressiveness of a patient’s disease, help predict survival outcomes and result in novel therapeutic strategies tailored to patients with the most adverse survival outcomes. When a patient’s tumor is identified as having elevated levels of these 10 specific genes, doctors may be able to better predict which treatments would be most effective, said Cheon, whose research was published in Clinical Cancer Research. That is an important advance because ovarian cancer is the most lethal gynecologic cancer and is often diagnosed in later, more aggressive stages, resulting in poor prognosis and survival. These outcomes differ due to development of tumors that become resistant to chemotherapy. …

Approaches to pain assessment in cancer clinical trials

A new paper published by Cancer External Site describes approaches to pain measurement used in oncology clinical trials submitted to the U.S. Food and Drug Administration that are consistent with current FDA guidance principles. The purpose of the paper is to assist drug developers to include meaningful pain endpoints when designing cancer trials. "Measurement of pain and other symptoms is an essential part of cancer trials…

Colon cancer researchers target stem cells, discover viable new therapeutic path

"This is the first step toward clinically applying the principles of cancer stem cell biology to control cancer growth and advance the development of durable cures," says principal investigator Dr. John Dick about the findings published online today in Nature Medicine…

Experimental regimen tested for small cell lung cancer

Small cell lung cancer, which includes oat cell carcinoma, is a more aggressive disease than other types of lung cancer and often is more advanced at the time of diagnosis. Smoking is the most common cause of the diagnosis and can be diagnosed even decades after an individual has quit. At advanced stages of the disease, it is incurable in the vast majority of patients, with a median survival less than 12 months. Mita said that following a diagnosis of small cell lung cancer, most patients opt for immediate chemotherapy using the standard-of-care chemotherapy’s etoposide and cisplatin — two drugs developed more than three decades ago…

Customizing treatments for deadly prostate cancer with tumor genomics

"Men with castration-resistant prostate cancer have abysmal survival rates, typically living an average of two years once hormone therapies fail," says Manish Kohli, M.D., a Mayo Clinic oncologist and principal investigator of the Prostate Cancer Medically Optimized Genome-Enhanced Therapy (PROMOTE) study. Dr. Kohli says the poor prognosis for men with this cancer highlights the need for studies like PROMOTE, which seek to match new targeted drugs with the genomic characteristics of individual patients’ tumors. Several new therapies have recently been approved by the FDA for use in treating castration-resistant prostate cancer, offering new hope for men with this disease. …

Earlier onset of puberty in girls linked to obesity

Published online Nov. 4, the multi-institutional study strengthens a growing body of research documenting the earlier onset of puberty in girls of all races. "The impact of earlier maturation in girls has important clinical implications involving psychosocial and biologic outcomes," said Frank Biro, MD, lead investigator and a physician in the Division of Adolescent Medicine at Cincinnati Children’s Hospital Medical Center. "The current study suggests clinicians may need to redefine the ages for both early and late maturation in girls." Girls with earlier maturation are at risk for a multitude of challenges, including lower self-esteem, higher rates of depression, norm-breaking behaviors and lower academic achievement. …

Largest-ever study of male breast cancer treatment shows more mastectomy, less radiation than in females

"We know very little about male breast cancer since it comprises only 0.6 percent of all breast cancer, and nearly all therapy is based on female breast cancer studies. This study demonstrates that just as in women, men with early stage breast cancer have the same outcome with a mastectomy or a lumpectomy followed by radiation. In women, breast-conserving surgery is the standard and preferred treatment for the majority of women…

Walking program shows promise in reducing joint stiffness in older breast cancer survivors on aromatase inhibitor therapy

Postmenopausal women with breast cancer whose treatment generally includes an aromatase inhibitor, or AI, often experience joint pain or stiffness known as AI-associated arthralgia. An estimated 20 to 32 percent of these women stop taking their AI due to this side effect. Researchers at the University of North Carolina at Chapel Hill conducted a pilot study to assess the potential positive effects of physical activity on joint pain and stiffness in these patients, as a potential alternative or adjunctive approach to arthralgia management that would enable them to continue their cancer therapy while living as pain- free as possible. "We were interested in seeing if a physical activity program that is evidence-based for reducing joint pain, stiffness and fatigue in adults with arthritis might have similar benefits for women experiencing AI- associated arthralgia," says Kirsten A…