Previously considered protective, SIRT6 is part of a family of seven proteins called sirtuins that help regulate genomic stability and prevent some of the genetic flaws associated with aging. …
The new study, published in The FASEB Journal, has found that this clock activity in turn regulates the cycle of all cells in the body. The team of researchers also discovered that the local biological clock and its control are weakened in aging bladders, demonstrating the importance of the clock in bladder physiology and aging. While currently much is known about the central biological clock, little is known about the peripheral clocks in the body. This latest research challenges the long-held view that the central clock of the brain controls all the peripheral clocks in other parts of the body and that these in turn control the down-stream receptor molecules which generate specific cell activities, such as contraction, secretion and metabolism…
source : http://www.sciencedaily.com/releases/2014/03/140327142443.htm
One strategy, which occurs in about 90 percent of cancers, requires increase production of a telomere-elongating enzyme called telomerase. A less understood strategy, employed by the remaining 10-15 percent of cancers, is called ALT (for Alternative Lengthening of Telomeres). Previously, biologists knew ALT existed simply because tumor cells could rebuild long, albeit unkempt-looking telomeres without telomerase. …