Tag Archives: multiple

Insight on cell migration, movement of cancer cells

Jordi Casanova, head of the "Morphogenesis in Drosophila" lab at IRB Barcelona and CSIC research professor, and Gaëlle Lebreton, postdoctoral fellow in the same group, have published a study performed using Drosophila melanogaster in the Journal of Cell Science. This work reveals that in a multiple movement, a single cell can act as the leader and can drag the rest with it. The scientists have studied the tracheal development of Drosophila in vivo and describe the morphological characteristics of the leading cell and provide molecular details about how it drives the movement. "Cancer researchers are keen to know how cells are organized to achieve migration and to form new capillaries to feed an expanding cancerous tumor," explains Gaëlle Lebreton, first author of the article. …

Chemists’ work will aid drug design to target cancer and inflammatory disease

The researchers, from the lab of Charles Dann III, assistant professor of chemistry in the College of Arts and Sciences, published their findings in the Proceedings of the National Academy of Sciences. Dann said the results should help chemists create more effective antifolate drugs, which act by interfering with the ability of folates — also called folic acid or vitamin B9 — to perform tasks that are essential for cell growth. …

Keeping centrioles in check to ensure proper cell division

Their results are published in the journal Current Biology today. Centrioles — orchestrators of cell division When our cells divide, their genetic material — in the form of X-shaped chromosomes — is aligned in the middle of the cell and segregated to opposite poles of the cell by a spindle of long tubular fibers, so-called microtubules. The structures that organize the two poles of the spindle in animal cells are called centrosomes…