Tag Archives: lymph

How lymph nodes expand during disease

The immune system defends the body from infections and can also spot and destroy cancer cells. Lymph nodes are at the heart of this response, but until now it has never been explained how they expand during disease. The researchers — at Cancer Research UK’s London Research Institute — found that when a type of immune cell, called dendritic cells, recognises a threat they make a molecule called CLEC-2 that tells the cells lining the lymph nodes to stretch out and expand to allow for an influx of disease fighting cells. It’s long been known that these same dendritic cells patrol the body searching for threats and call for reinforcements to tackle them…

Mammography screening intervals may affect breast cancer prognosis

In its earliest stages, breast cancer is confined to the breast and can be treated by surgically removing the cancer cells. As the disease progresses, breast cancer cells may spread to the lymph nodes and then to other areas of the body. "On its pathway to other places in the body, the first place breast cancer typically drains into before metastasizing is the lymph nodes," said Lilian Wang, M.D., assistant professor of radiology at Northwestern University/Feinberg School of Medicine in Chicago, Ill. "When breast cancer has spread into the lymph nodes, the patient is often treated both locally and systemically, with either hormone therapy, chemotherapy, trastuzumab or some combination of these therapies." Historically, healthcare organizations, such as RSNA and the American Cancer Society (ACS), have recommended annual screening with mammography for women beginning at age 40. …