Breakthrough in understanding how cancer cells metastasize
The study examined the function of a protein called DENND2B. During childhood development, DENND2B likely plays a role in the normal migration of cells. In adults, cell migration is greatly reduced, but in the case of cancer, there is unwanted cell migration, contributing to one of the most puzzling aspects of cancer cells — metastasis to new locations. “DENND2B activates another protein in the cell called Rab13, which is an enzyme that promotes cell migration,” says Dr. …