By mapping the specific steps that cells of melanoma, breast cancer and a blood cancer called myelofibrosis use to become resistant to drugs, the researchers now have much better targets for blocking those pathways and keeping current therapies effective. The findings are published in two papers Dec…
Their findings will be reported online Dec. 6 in the New England Journal of Medicine, and presented on Dec. …
Bladder cancer is the fourth most common non-skin cancer. But there is no good screening test for it, and there has been limited progress in characterizing how aggressive an individual’s bladder cancer will be. Loyola researchers studied microscopic droplets, called exosomes, that are shed by cancer cells and are found in urine. Understanding the biology of exosomes could lead to the development of a screening test, which would require a simple urine sample, said lead researcher Gopal Gupta, MD. …
Cancer is due to changes in the DNA of cells, which causes them to divide in an uncontrolled manner. It is also true that the cancer cells in certain common tumours, such as in colon cancer, can have over 100 chromosomes instead of the 46 chromosomes normally present in a human cell. But does a single, initial change in the number of chromosomes set off a sequence of unstoppable changes that lead to cancer? The answer to this question is important; in order to ensure that cancer research is on the right track…
The findings, published in the journal Lancet Oncology, investigated the timing of trastuzumab administration with anthracycline and taxane chemotherapy. "In a previous MD Anderson study concurrent administration of trastuzumab with chemotherapy, including anthracyclines, demonstrated high pathologic complete response rates in breast cancer patients with HER-2-positive disease," Buzdar said. …