A team of researchers at the Massachusetts General Hospital and Harvard Medical School in Boston has developed technologies for precision measurement of cell migration speed before and applied the new tool to study the variations of migration speed in population of cancer cells. This tool enabled comparisons between successive generations of cells with single cell resolution…
The chemists, led by Professor Peter Scott at the University of Warwick, UK, have been able to produce molecules that have a similar structure to peptides which are naturally produced in the body to fight cancer and infection. Published in Nature Chemistry, the molecules produced in the research have proved effective against colon cancer cells in laboratory tests, in collaboration with Roger Phillips at the Institute for Cancer Therapeutics, Bradford, UK…
source : http://www.sciencedaily.com/releases/2014/04/140410083200.htm
source : http://www.sciencedaily.com/releases/2014/01/140130164317.htm
Reporting in the journal Cell Reports, researchers combined several types of data from pre- and post-treatment biopsies of breast tumors to obtain a molecular picture of how the cancer evolved as a result of chemotherapy. “Better understanding of tumor evolution is key to improving the design of cancer therapies and for truly individualized cancer treatment,” said Kornelia Polyak, MD, PhD, a breast cancer researcher. The model was developed by Polyak and Franziska Michor, PhD, a computational biologist at Dana-Farber. …
CTCs can also be tested to identify genetic mutations associated with a tumor. Many newer cancer medications are designed to target specific genetic mutations, so they work best for limited types and stages of cancer. CTCs can provide a quick method to help physicians choose the most appropriate targeted therapy for a particular patient…
Sergey Shityakov and Carola Förster of the University of Würzburg, Germany, explain that the protein, P-glycoprotein, acts as a gatekeeper, flushing out potentially harmful chemicals that enter the body as well as the naturally-occurring products of metabolism. …
To reduce the need for these second surgeries, four Johns Hopkins graduate students have designed a device to allow pathologists to quickly inspect excised breast tissue within 20 minutes, while the patient is still in the operating room. …
The researchers, led by Dr Cristina Tufarelli, in the School of Graduate Entry Medicine and Health Sciences, discovered that the presence of this faulty genetic element — known as chimeric transcript LCT13 — is associated with the switching off of a known tumour suppressor gene (known as TFPI-2) whose expression is required to prevent cancer invasion and metastasis. …