Tag Archives: cloud

New targeted drugs could treat drug-resistant skin cancer

Existing drugs target faulty versions of a protein called BRAF which drives about half of all melanomas, but while initially very effective, the cancers almost always become resistant to treatment within a year. The new drugs — called panRAF inhibitors — could be effective in patients with melanoma who have developed resistance to BRAF inhibitors…

Tool to better classify tumor cells developed for personalized cancer treatments

Just as cancer is not a single disease, but a collection of many diseases, an individual tumor is not likely to be comprised of just one type of cancer cell. In fact, the genetic mutations that lead to cancer in the first place also often result in tumors with a mix of cancer cell subtypes. The WPI team developed a new statistical model that uses an advanced algorithm to identify these multiple genetic subtypes in solid tumors by analyzing gene expression data from a small biopsy sample…

Early trial of new drug shows promise for patients with metastatic triple-negative breast cancer — ScienceDaily

The multi-center, non-randomized trial was designed to evaluate the safety, tolerability and antitumor activity of bi-weekly infusions of pembrolizumab (MK-3475, marketed as Keytruda�). The researchers enrolled 27 patients, aged 29 to 72 years, who had metastatic triple-negative breast cancer that either relapsed after treatment for early stage disease or progressed on therapy for advanced disease…

Pathway that degrades holiday turkey fuels metastasis of triple negative breast cancer — ScienceDaily

“I’m not saying that people with metastatic breast cancer shouldn’t eat turkey during the holidays, but triple-negative breast cancer appears to have found a way to process tryptophan more quickly, equipping cancer cells to survive while in circulation, which allows them to metastasize,” says Thomas Rogers, the paper’s first author and PhD candidate in the laboratory of CU Cancer Center investigator, Jennifer Richer, PhD. …

Measuring the Malignancy of Prostate Cancer — ScienceDaily

When cancer is diagnosed, the grade of its malignancy is a central concern for both patients and their physicians. This value is used to determine how intensively and how radically the cancer must be treated. Particularly in the case of prostate cancer, the disease can take widely varying courses in different patients…

Early trial of new drug shows promise for patients with metastatic triple-negative breast cancer

The multi-center, non-randomized trial was designed to evaluate the safety, tolerability and antitumor activity of bi-weekly infusions of pembrolizumab (MK-3475, marketed as Keytruda�). The researchers enrolled 27 patients, aged 29 to 72 years, who had metastatic triple-negative breast cancer that either relapsed after treatment for early stage disease or progressed on therapy for advanced disease. …

Women with dense breasts will have to look beyond ultrasound for useful supplemental breast cancer screening

In a study released Monday in the Annals of Internal Medicine, Tosteson and colleagues, including lead author Brian Sprague, MD, provide evidence on the benefits and harms of adding ultrasound to breast cancer screening for women who have had a negative mammogram and also have dense breasts. …

New breast cancer classification based on epigenetics

The identification of patients with high-risk breast cancer is key to knowing whether a patient will require only the removal of the tumor by surgery or whether if she will need additional chemotherapy to make sure the removal of breast cancer cells. Currently, known genetic mutations and expression patterns are determined, but the puzzle of the genetics of the disease remains a large unfinished part…