Tag Archives: cancer treatment

Unexpected discovery of the ways cells move could boost understanding of complex diseases

The study appears June 23, 2013 in an advance online edition of Nature Materials. "We were trying to understand the basic relationship between collective cellular motions and collective cellular forces, as might occur during cancer cell invasion, for example. But in doing so we stumbled onto a phenomenon that was totally unexpected," said senior author Jeffrey Fredberg, professor of bioengineering and physiology in the HSPH Department of Environmental Health and co-senior investigator of HSPH’s Molecular and Integrative Cellular Dynamics lab. Biologists, engineers, and physicists from HSPH and IBEC worked together to shed light on collective cellular motion because it plays a key role in functions such as wound healing, organ development, and tumor growth. …

Chemical that makes naked mole rats cancer-proof discovered

The findings could eventually lead to new cancer treatments in people, said study authors Andrei Seluanov and Vera Gorbunova. Their research paper will be published this week in the journal Nature. Naked mole rats are small, hairless, subterranean rodents that have never been known to get cancer, despite having a 30-year lifespan. …

New resistance mechanism to chemotherapy in breast and ovarian cancer

The team led by Spanish National Cancer Research Centre researcher Óscar Fernández-Capetillo, head of the Genomic Instability Group, together with researchers from the National Cancer Institute in the US, have participated in a study that describes the causes that explain why tumours with BRCA1 and BRCA2 mutations stop responding to PARP inhibitor drugs. "PARP inhibitors are only toxic in tumours that have an impaired DNA repair mechanism, such as those that contain BRCA1/2 mutations" says María Nieto-Soler, a researcher from Fernández-Capetillo’s team…

In-flight emergencies: Not as common as you think

Medical emergencies can occur at any time and that means, even while you’re on vacation or flying to your destination. But don’t be alarmed; you may be surprised as to how rare they are. A recent study published in the New England Journal of Medicine investigated the outcomes of medical emergencies on commercial flights between 2008 and 2010.   They found that for every 1 million passengers, 16 emergencies occurred – in other words, one emergency for every 600 flights.   The most common emergencies included fainting at 37.4 percent, respiratory symptoms at 12.1 percent and nausea or vomiting at 9.5 percent.  Interestingly, cardiovascular events like cardiac arrest, and obstetric or gynecological issues each accounted for less than or equal to 0.5 percent.   The Federal Aviation Administration (FAA) mandates that all aircraft carry an emergency medical kit.  These kits are required to have, among other things, aspirin tablets, nitroglycerine tablets, saline solution and epinephrine. These kits are designed to provide flight crew or on-board medical professionals with resources to treat ill passengers, after consulting a ground-based physician in a medical communication center.   According to the report, flights had to be diverted and land at a different destination in only 7.3 percent of the cases.  Often, the reason flights were able to continue to the original destination is because of the training of the flight crew, the supplies in mandatory medical kits and the presence of medical professionals on board.   Oxygen was the most commonly used treatment almost 50 percent of the time, followed by saline solution at 5.2 percent and aspirin at 5 percent. This study does a nice job quantifying the incidence of in-flight medical emergencies and the resulting treatments and providers.   Keep in mind that such medical emergencies are rare, but do occur daily given the vast amount of airline travel across the world.   Rest assured that traveling physicians and other medical professionals are often on board and able to help ill passengers; at minimum, the flight crew will have contact with a physician at an academic medical communication center to remotely aid in treatment.  Dr. David B. Samadi is the Vice Chairman of the Department of Urology and Chief of Robotics and Minimally Invasive Surgery at the Mount Sinai School of Medicine in New York City. He is a board-certified urologist, specializing in the diagnosis and treatment of urological disease, with a focus on robotic prostate cancer treatments. To learn more please visit his websites RoboticOncology.com and SMART-surgery.com. Find Dr. Samadi on Facebook.source : http://www.foxnews.com/health/2013/06/05/in-flight-emergencies-not-as-common-as-may-think/

New therapy shown to improve progression-free survival and shrink tumors in rare cancer for the first time

The findings are potentially practice-changing for a historically "untreatable disease." Though uveal melanoma is rare — there are only 2,500 cases diagnosed in the United States each year — about half of patients will develop metastatic disease, and survival for patients with advanced disease has held steady at nine months to a year for decades. Researchers found that progression-free survival (PFS) in patients receiving selumetinib was nearly 16 weeks and 50 percent of these patients experienced tumor shrinkage, with 15 percent achieving major shrinkage. Patients receiving temozolomide, the current standard chemotherapy, had seven weeks of PFS and no tumor shrinkage. …

New technology makes breast cancer surgery more precise

Surgeons at UC Irvine Medical Center are the first in the country to use a device that reduces by half the need to reoperate and cut out breast cancer cells missed during an initial lumpectomy. The MarginProbe System lets the surgeon immediately assess whether cancer cells remain on the margins of excised tissue. Currently, patients have to wait days for a pathologist to determine this…