Tag Archives: cambridge

New plan of attack in cancer fight: Two-drug combination, under certain circumstances, can eliminate disease

As described in a paper recently published in eLife, Martin Nowak, a professor of mathematics and of biology and director of the Program for Evolutionary Dynamics, and co-author Ivana Bozic, a postdoctoral fellow in mathematics, show that, under certain conditions, using two drugs in a "targeted therapy" — a treatment approach designed to interrupt cancer’s ability to grow and spread — could effectively cure nearly all cancers. Though the research is not a cure for cancer, Nowak said it does offer hope to researchers and patients alike. "In some sense this is like the mathematics that allows us to calculate how to send a rocket to the moon, but it doesn’t tell you how to build a rocket that goes to the moon," Nowak said…

Proteins involved in immunity potentially cause cancer

The proteins are part of a group called apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) cytidine deaminases. The investigators found that APOBEC mutations can outnumber all other mutations in some cancers, accounting for over two-thirds in some bladder, cervical, breast, head and neck, and lung tumors. The scientists published their findings online July 14 in the journal Nature Genetics. Dmitry Gordenin, Ph.D., is corresponding author of the paper and a senior associate scientist at the National Institute of Environmental Health Sciences (NIEHS), part of NIH. …