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No link found between bladder cancer, use of pioglitazone or rosiglitazone, Avandia — ScienceDaily

Bladder cancer is the ninth most common cancer in the world, with 430,000 new cases diagnosed in 2012. Europe and North America have the highest incidence of bladder cancer, with an even higher incidence in people with diabetes. Bladder tumours overexpress a natural part of the cell machinery, a transcription factor in the cell nucleus known as ‘peroxisome proliferator-activated receptor gamma’ (or PPARγ) that is found in the urothelium (the lining of the urinary tract). Both pioglitazone and rosiglitazone are part of the thiazolidinediones (TZDs) class of drugs, which act as PPARγ agonists, meaning they induce the same action as PPARγ…

Technology breakthrough reveals cellular transcription process

The technology is known as the “FISH investigation protocol” (Fluorescent in situ hybridization) — it optimises current flow cytometry processes, resulting in a greater visibility of the transcription of RNA, a key step in the transmission of cellular information. …

Psychological problems in men experiencing cancer

A group of 127 men aged 18 and over with a cancer diagnosis were recruited through the National Health Service and cancer charities between April 2009 and April 2011. The participants were assessed for demographic factors, social support, anxiety and depression, and distress (Distress Thermometer)…

Men with life expectancies of less than 10 years still receive aggressive treatment for prostate cancer despite guidelines — ScienceDaily

In the first study to rigorously address prostate cancer treatment trends by life expectancy in a large, nationally representative sample, UCLA researchers found that more than half of prostate cancer patients 66 years and older have life expectancies of less than10 years, but half of those still were over-treated for their prostate cancer with surgery, radiation or brachytherapy, the implantation of radioactive seeds in the prostate. Randomized controlled studies have suggested that significant differences in survival between watchful waiting — monitoring the cancer closely but not treating it — and aggressive therapies don’t develop until 10 years after treatment. It only makes sense to not treat men expected to die of something else within 10 years…

Innovative ‘Tumor in a Dish’ Turns Cells Into Cancer

By combining the different cells that make up a lung, Dr. Anant was able to insert cancer cells and see how they grew in a real “in vivo” environment, or one that closely resembles human anatomy. The process could also make it quicker and easier to test standard and experimental drugs on individual cancers as current drug testing methods can be time-consuming, imprecise or controversial. For example, while genetic testing has become easier, it often shows what treatments won’t work as opposed to which ones will. …

Not all induced pluripotent stem cells are made equal

This means the type of cell obtained from an individual patient to make pluripotent stem cells, determines what can be best done with them. For example, to repair the lung of a patient with lung disease, it is best to start off with a lung cell to make the therapeutic stem cells to treat the disease, or a breast cell for the regeneration of tissue for breast cancer patients…

New molecules to burst malaria’s bubble

A new paper in PNAS is the third published recently by a group at the Australian National University (ANU). The group has collaborated with scientists from around the globe to uncover potential ammunition in the fight against malaria. Over 200 million people contract malaria each year, and the parasite that causes the disease has become resistant to most of the drugs currently available…