Tag Archives: biology

Cetuximab or bevacizumab with combi chemo equivalent in KRAS wild-type MCRC

“The CALGB/SWOG 80405 trial was designed and formulated in 2005, and the rationale was simple: we had new drugs –bevacizumab and cetuximab– and the study was designed to determine if one was better than the other in first-line for patients with colon cancer,” said lead study author Alan P. Venook, distinguished Professor of Medical Oncology and Translational Research at the University of California, San Francisco, USA. The CALGB/SWOG 80405 trial studied patients whose tumours were KRAS wild-type at codons 12 and 13. …

Why don’t genetically identical cells behave identically? Cellular noise

Dohlman, a professor of biochemistry and biophysics in the UNC School of Medicine, is like a mechanic for cells. He takes them apart to see how they function. He can tell you what part is like a gas pedal — a protein that pushes a brain chemical into action, for instance. And he can tell you which part is like the brakes — a protein that counteracts the effect of the gas pedal…