Virus-fighting genes linked to mutations in cancer: Genetic evidence supports role of gene family in cancer development — ScienceDaily
source : http://www.sciencedaily.com/releases/2014/04/140413135912.htm
Tag Archives: apobec
Proteins involved in immunity potentially cause cancer
The proteins are part of a group called apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) cytidine deaminases. The investigators found that APOBEC mutations can outnumber all other mutations in some cancers, accounting for over two-thirds in some bladder, cervical, breast, head and neck, and lung tumors. The scientists published their findings online July 14 in the journal Nature Genetics. Dmitry Gordenin, Ph.D., is corresponding author of the paper and a senior associate scientist at the National Institute of Environmental Health Sciences (NIEHS), part of NIH. …