Category Archives: Cancer Treatment

Targeted therapy boosts lung cancer outcomes

In a trial involving patients with non-small cell lung cancer (NSCLC) whose tumor cells harbored an abnormal ALK gene, those who received the oral drug crizotinib, which acts directly on ALK, went a median time of 7.7 months before their disease began to worsen, compared to 3 months for patients who received traditional chemotherapy. Patients treated with crizotinib also had a better quality of life than those treated with standard chemotherapy. The findings will be released as an advanced online publication by the New England Journal of Medicine on June 1. …

New technology makes breast cancer surgery more precise

Surgeons at UC Irvine Medical Center are the first in the country to use a device that reduces by half the need to reoperate and cut out breast cancer cells missed during an initial lumpectomy. The MarginProbe System lets the surgeon immediately assess whether cancer cells remain on the margins of excised tissue. Currently, patients have to wait days for a pathologist to determine this…

Dealing with the side effects of cancer treatment

Are the side effects of cancer treatment worse than the cancer itself? My immediate response to that question is ‘Yes.’  But for me, the reality is that I have stage 4 cancer, so I have no choice but to suck it up.  As awful as this chemo is, I have to try, try, try to focus on the fact that it is working.  I just hate the way it makes me feel. When I was admitted into this phase one clinical trial , I was elated – even more so when I was told this drug had no side effects. “This is fantastic!” I thought.  It seemed almost too good to be true.  And of course, it was. I am exhausted.  My white count, red count and platelet levels are dangerously low.  The neuropathy in my feet is getting worse, and I now have jaw necrosis – which basically involves having your gums disappear, leaving jaw bone exposed. Talk about pain! Alright, enough complaining. No one wants to read bad news, so I apologize. I am just so tired of all of it.  But, I need to focus on the fact that this drug seems to be working, and the cancer in my liver has decreased a smidgeon, which is positively awesome. I want to share with you an example of how one small group of students put thought and effort in motion to make a difference.  I received a letter this week from the principal of St. Simon the Apostle School in Indianapolis, with a check enclosed for $1,177.  Last October, the students added pink accessories – pink socks, pink nail polish, etc. – to their uniforms in an effort to raise money for breast cancer awareness and to honor relatives who have fought this disease.  They made this donation to my foundation in honor of their math teacher who is retiring after 17 years.  Wow!  I am so honored that they would think of The Noreen Fraser Foundation and trust us to spend their money wisely.  And we will! Thank you to all the young kids and teenagers who move beyond self-indulgence to think of others and show compassion to those who are struggling.Noreen Fraser is living with Stage IV metastatic breast cancer. She is the Founder and CEO of the Noreen Fraser Foundation, a 501(c)(3) non-profit organization dedicated to funding groundbreaking women's cancer research.& To stay in touch with Noreen, please 'LIKE' The Noreen Fraser Foundation on Facebook and follow her on Twitter. & Noreen can be contacted via email at noreen@noreenfraserfoundation.org.source : http://www.foxnews.com/health/2013/05/30/dealing-with-side-effects-cancer-treatment/

New possibilities for prostate cancer treatment revealed

Published today in Science Translational Medicine, a study led by Monash University researchers has found prostate cancer cells that survive androgen withdrawal treatment. Previously unidentified, these cells are potential targets for future treatments. As they are present early in disease development, there is the possibility of therapy before the cancer reaches the aggressive, incurable stage. Prostate cancer is the most common form of cancer in men, with around 20,000 new cases diagnosed each year in Australia…

Kidney stones: Symptoms and treatment

Chances are you or someone you know has had a kidney stone at some point in their life; they are very common, affecting approximately one in ten people throughout their lifetime.  The risk of kidney stones is higher in the United States than the rest of the world and this number has only been increasing over the past two to three decades.  Despite the high incidence in the U.S., however, this is a condition that affects people worldwide and has done so for millennia; bladder and kidney stones have even been found in Egyptian mummies. Kidney stones are small, hard deposits, typically composed of mineral and acid salts, that form inside your kidneys.  As one might expect, because urine is a vehicle for waste excretion, it is comprised of numerous chemicals and wastes (including calcium, oxalate, urate, cysteine, xanthine and phosphate).  When the urine is too concentrated, that is too little liquid and too much waste, crystals will begin to form.  Over time, these crystals can join together and form a larger stone-like solid.   There is no single cause for kidney stones and often, the cause is unknown.  There are, however, different types of kidney stones, which can help pinpoint the origin.  Calcium stones (in the form of calcium oxalate or calcium phosphate), for example, are the most common form of kidney stone.  Oxalate is a naturally occurring substance in food, so anything that increases levels of this compound, can increase the risk of a kidney stone.  Uric acid stones often form in people who do not consume enough fluids, eat high protein diets or have gout.  Struvite stones often form as the result of a kidney infection.   Treatment for kidney stones primarily depends on the size of the stone.  If it is smaller than four millimeters in diameter, you have a good chance of passing it spontaneously. Consuming two to three quarts of water a day and using a pain reliever can help pass these small stones.  Larger stones may require invasive treatment including: surgery, using a scope passed through the urethra or shock-wave lithotripsy, where high-energy sound waves break up the stone in to more easily passable stones. Risk factors for developing kidney stones include: being over age 40, being male, ingesting too little water, too much/little exercise, obesity, weight loss surgery, digestive diseases, and consuming a diet high in salt, protein or sugar, especially fructose.  Having a family history of kidney stones can also increase your risk of developing them; furthermore, if you have already experienced kidney stones, you are at an increased risk of developing more.   Prevention of kidney stones can be as simple as a few dietary changes.  Consuming more water during the day is one of the easiest measures you can take.  Doctors recommend excreting about 2.6 quarts of urine every day.  Depending on the severity of your kidney stones, you may want to measure and monitor your urine excretion.  Consume fewer oxalate-rich foods, especially if you tend to form calcium oxalate stones.  Such foods include chocolate, soy products, okra, beets, sweet potatoes, tea and nuts.  Consume foods low in salt and animal protein.  Speak with your doctor about your calcium intake via food and supplements before making any changes here.  Furthermore, speak with your doctor about the possibility of prescription drugs to help with your kidney stones.  Dr. David B. Samadi is the Vice Chairman of the Department of Urology and Chief of Robotics and Minimally Invasive Surgery at the Mount Sinai School of Medicine in New York City. He is a board-certified urologist, specializing in the diagnosis and treatment of urological disease, with a focus on robotic prostate cancer treatments. To learn more please visit his websites RoboticOncology.com and SMART-surgery.com. Find Dr. Samadi on Facebook.source : http://www.foxnews.com/health/2013/05/29/kidney-stones-symptoms-and-treatment/

Cholesterol sets off chaotic blood vessel growth

The work, led by Yury Miller, MD, PhD, associate professor of medicine at UC San Diego, will be published in the advance online edition of the journal Nature on May 29. Cholesterol is a structural component of the cell and is indispensable for normal cellular function, although its excess often leads to abnormal proliferation, migration, inflammatory responses or cell death. The researchers studied how the removal of cholesterol from endothelial cells (cells that line the blood vessels) impacts the development of new blood vessels, the process called angiogenesis. According to Miller, removal of excess cholesterol from endothelial cells is essential for restraining excessive growth of blood vessels. …

Shape-shifting nanoparticles flip from sphere to net in response to tumor signal

Spherical nanoparticles labeled with red or green dye shift their shapes and accumulatte into netlike structures when they encounter a protease secreted by some kinds of cancerous tumors (Click on image for larger view). Targeting treatments specifically to cancerous or other diseased cells depends on some means of accumulating high levels of a drug or other therapeutic agent at the specific site and keeping it there. Most efforts so far depend on matching a piece of the drug-delivering molecule to specific receptors on the surface of the target cell. …

Novel class of drugs for prostate cancers

In men with advanced prostate cancer, growth of cancer cells depends on androgen receptor signaling, which is driven by androgens, such as testosterone. To thwart tumor growth, most patients with advanced prostate cancer receive drugs that block the production of androgen or block the receptor where the androgen binds. Unfortunately, such treatments invariably fail and patients die of prostate cancer with their androgen receptor signaling still active and still promoting tumor growth. In the new study, available online at Nature Communications, a team of researchers led by Dr. …

Modulating the immune system to combat metastatic cancer

In this issue of the Journal of Clinical Investigation, researchers led by Ronald Levy at Stanford University found that regulatory T cells that infiltrate tumors express proteins that can be targeted with therapeutic antibodies. Mice injected with antibodies targeting the proteins CTLA-4 and OX-40 had smaller tumors and improved survival. …

Scientists discover how rapamycin slows cell growth

"Cells normally monitor the availability of nutrients and will slow down or accelerate their growth and division accordingly. A key monitor of nutrients is a protein called the Target of Rapamycin (TOR), but we do not know the details of how this protein feeds signals downstream to control growth" says Dr. Stephen Michnick, senior author and a University of Montreal biochemistry professor…