Category Archives: Cancer Knowledge

Live and let-7: microRNA plays surprising role in cell survival

Specifically, principal investigator Albert R. La Spada, MD, PhD, professor of cellular and molecular medicine, chief of the Division of Genetics in the Department of Pediatrics and associate director of the Institute for Genomic Medicine at UC San Diego, and colleagues found that a microRNA known as let-7 controls autophagy through the amino acid sensing pathway, which has emerged as the most potent activator of mTORC1 complex activity. Autophagy is a fundamental process used by cells to degrade unnecessary components in times of starvation, releasing energy stores that help promote cell survival…

A diet for the cell: Keeping DNA fit with fewer calories

Cells harbour genetic material in the form of DNA, which contains all the information required for the cell to function. Every time a cell divides this information has to be precisely copied so that the newly made cell receives a perfect replica in order that it, too, can function properly. …

Thyroid carcinoma: Biomarker reveals cancer cause

CLIP2 serves as a radiation marker: After exposure to radiation from radioiodine, both the genetic activity and the protein expression are increased, as the scientists’ studies were able to substantiate. CLIP2 appears to be particularly significant in the development of tumours in the thyroid gland after radiation exposure…

New ‘lab-on-a-chip’ could revolutionize early diagnosis of cancer

“Exosomes are minuscule membrane vesicles — or sacs — released from most, if not all, cell types, including cancer cells,” said Yong Zeng, assistant professor of chemistry at the University of Kansas. “First described in the mid-’80s, they were once thought to be ‘cell dust,’ or trash bags containing unwanted cellular contents. …

Link between breast implants, cancer under investigation

Worldwide there have been 71 documented cases of patients with anaplastic large cell lymphoma (ALCL) in which researchers suspected breast implants to be the cause. ALCL is normally found in the lymph nodes, as well as in skin, lung, liver and soft tissue, but not usually in the breast. Cases in which ALCL developed in the breast region almost exclusively involved patients who have had breast surgery. …

The skin cancer selfie: Gigapixel camera helps diagnose early

Developed by a team of researchers at Duke University in North Carolina, USA, the “gigapixel whole-body photographic camera” is essentially three dozen cameras in one, allowing the researchers to image the entire body down to a freckle. The research will be presented at The Optical Society’s (OSA) 98th Annual Meeting, Frontiers in Optics, being held Oct. 19-23 in Tucson, Arizona, USA. …

Neuroscientists use snail research to help explain ‘chemo brain’

In an effort to solve this mystery, neuroscientists at The University of Texas Health Science Center at Houston (UTHealth) conducted an experiment in an animal memory model and their results point to a possible explanation. Findings appeared in The Journal of Neuroscience. In the study involving a sea snail that shares many of the same memory mechanisms as humans and a drug used to treat a variety of cancers, the scientists identified memory mechanisms blocked by the drug. …

Gene can predict aggressive prostate cancer at diagnosis — ScienceDaily

The results reported in the journal of Clinical Cancer Research, a publication of the American Association of Cancer Research, indicate the KLK3 gene — a gene on chromosome 19 responsible for encoding the prostate-specific antigen (PSA) — is not only associated with prostate cancer aggression, but a single nucleotide polymorphism (SNP) on it is more apparent in cancer patients with GS7. Researchers have linked Gleason score, an important predictor of prostate cancer outcomes, to several clinical end points, including clinical stage, cancer aggression and survival. …