The role of radiotherapy after rectal cancer surgery

By | January 2, 2012

Straight cancer radiotherapy after surgery is the main advantage is observed and after surgery on the basis of pathological analysis of specimens, to make the best choice. Thus excluding early cases or patients who have distant metastases. Pelvic radiotherapy group randomized trial of 6, only one set of results was significantly lower local recurrence rate.Role in cancer radiotherapy after surgery, all experimental groups failed to demonstrate the role of increased survival rate, 27% of the patients can not be subject to treatment, mainly due to acute diarrhea caused. Treatment related mortality was 1% to 3%. Moreover, the strict analysis of the case, late small bowel toxicity reported up to 40%.
Role in cancer radiotherapy after surgery, radiotherapy from the treatment of rectal cancer after surgery than the point of view is clearly more harm than, so many ideas now after surgery while chemotherapy and radiotherapy, radiotherapy alone should be abandoned. Cancer experience of radiotherapy and chemotherapy after surgery began in the mid-19th century, 70 the United States, while giving chemotherapy aimed at increasing the local effects of radiotherapy and reduce distant metastasis. The treatment program consists of two series components: Concurrent chemotherapy and radiotherapy plus chemotherapy. Two randomized studies testing the program showed that the cancer program of radiotherapy and chemotherapy after surgery compared with surgery alone, postoperative chemotherapy and postoperative radiotherapy on local recurrence, distant metastasis and improve survival rates have a significant interest. Postoperative radiotherapy and chemotherapy during the early days, as many as 60% of patients had severe acute toxicity, mainly diarrhea and (or) neutropenia, or nearly 5% treatment-related mortality.
The role of rectal cancer radiation therapy after surgery, years of clinical observation, reduced the number of cycles of chemotherapy (from 8 cycles to 2 cycles), increased by radiotherapy (with fieldwork in the second field instead of radiation exposure), the introduction of quality control procedures to reduce the toxicity of mortality rates (to nearly 0.5%) and late toxicity rates. However, postoperative radiotherapy and chemotherapy may affect the retention of the sphincter function, further research in the future must be carefully assessed. Cancer radiotherapy and chemotherapy after surgery is recommended as E and IV, of the standard treatment for rectal cancer patients, because of its potential toxic effects, should only be used after radiotherapy and chemotherapy are at high risk of recurrence, and require a professional, quality assurance way to get the best treatment ratio. This is not to consider preoperative radiotherapy with postoperative radiotherapy and chemotherapy approach.

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