What is Hodgkin lymphoma, all

By | May 1, 2012

What is Hodgkin lymphoma whole, Hodgkin lymphoma is the main histological features scattered single-core, multi-core or dual-core symmetric huge tumor cells (respectively known as Hodgkin's cells or Reed-Sternberg cells), and its a variety of backgrounds, compared with non-neoplastic reactive inflammatory cells, including lymphocytes, plasma cells, eosinophils and other cellular components and matrix fibrosis.
1969 will be reported in Rye classification of Hodgkin's lymphoma is divided into lymphocyte predominance, nodular sclerosis, mixed cell type (mixedcellularity, MC) and lymphocytes 4 types of mitigation type, is still being widely used. The newly established WHO 2001 classification system made on this basis only minor changes, an increase of lymphocyte-rich classical type of a type. According to the new WHO classification, Hodgkin lymphoma can be divided into: nodular lymphocyte predominant HL and classical HL, which is further divided into: nodular sclerosis, lymphocyte-rich classical type, mixed cell and lymphocyte reduction type.
What is a full-Hodgkin lymphoma 1. Nodular lymphocyte predominant Hodgkin lymphoma
NLPHL) NLPHL is nodular or nodular and diffuse pleomorphic characterized by monoclonal proliferation of B cell tumor, malignant tumor cells tend to spread and typical Reed-Sternberg cell morphology are different, and often over great mononuclear cells, scarce cytoplasm, often has folded or lobulated nucleus, known as popcorn cells (popcorn cell) or lymphocytes and / or tissue cells of the RS cell variant cells (lymphocyticand / or histiocytic cell, L / H cell). The L / H cell is full of non-tumor cells in follicular dendritic cell processes form a network among the big ball. Immunophenotype: CD20 ten, CD79 ten, BCL6 ten, CD45 ten, EMA + / A, CD15 a, CD30 one. Genetic characteristics: Ig gene rearrangements can be detected.
2. Classical Hodgkin lymphoma (clwsic Hodgkin's lymphoma) is characterized by classical HL visible tumor typical Reed Sternberg cells or mononuclear Hodgkin cells, the immune phenotype of tumor cells positive for CD30, CD15 are most positive. Containing different amounts based on the background of small lymphocytes, eosinophils, neutrophils, histiocytes, plasma cells, fibroblasts and collagen fibers mixed reactions infiltration characteristics and morphology of HRS cells, classical Hall Odd lymphoma can be divided into four histological subtypes: lymphocyte rich classical Hodgkin lymphoma, nodular sclerosis Hodgkin lymphoma, mixed cellularity Hodgkin's lymphoma and lymphocyte reduction of Hodge type lymphoma. The histological subtypes of immunophenotype and genetic features are the same, but their clinical characteristics and relationship with the EBV are different. Immunophenotype: CD30 +, CD15 ten (75% _85%), CD20 +1 a, CD79 one, BCL6 one, CD45 a, EMA, ALK-1 A, LMP-1 ten / one. Genetic characteristics: Ig gene rearrangements can be detected.
(1), lymphocyte rich classical Hodgkin lymphoma: a wealth of small lymphocytes, the lack of neutrophils and eosinophils in the diffuse background and scattered HRS cells characterized by classical HL. Mainly involving the superficial lymph nodes, mediastinal lymph node involvement and a huge mass rare.
(2) nodular sclerosis Hodgkin lymphoma (nodular sclerosis Hodgkin's lymphoma, NSHL): with at least one nodule surrounded by collagen bundles and fractured characteristics of HRS cells in classical HLo NSHL more common in young women, the most often involving the mediastinum, EBV-encoded LMP-1 expression is low (10% -40%).
(3) mixed cellularity Hodgkin lymphoma (mixed cellularity Hodgkin's lymphoma, MCHL): in the diffuse or vague nodular mixed inflammatory cells in the context of HRS is characterized by the typical spread of classical HL. MCHL adult common, the lack of nodular sclerosing lesions of fibrosis. Most commonly involving the superficial lymph nodes, often involving the spleen, but rare mediastinal involvement, B symptoms common. EBV-encoded LMP-1 expression rate (75%).
What is Hodgkin lymphoma wide (4) lymphocytes reduction of Hodgkin lymphoma (lymphocyte depletion Hodgkin's lymphoma, LDHL): the rich pleomorphic HRS cells and (or) non-neoplastic cells characterized by the classic cut Type HL, often accompanied by diffuse fibrosis. Most commonly involving the abdominal organs, retroperitoneal lymph node and bone marrow, superficial lymph nodes are less often clinically advanced, 80% had B symptoms, often accompanied by HIV and EBV infection. LDHL the most rare, many cases previously diagnosed as LDHL, now known to have the majority of anaplastic large cell or diffuse non-Hodgkin's lymphoma, and some may be cut variants NSHL lymphocytes.

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