What is a tumor necrosis factor, tumor necrosis factor (TNF) including TNF from macrophages and lymphocytes from TNF. TN of a known , since all have multiple biological activities, including regulation of vascular endothelial cell properties, inducing other cytokines, induction of antiviral activity, stimulation of bone resorption, angiogenesis, and fibroblast growth and so on. Its anti-tumor mechanism includes:
(1) in vitro that TNF has a direct dissolution of the tumor and inhibition of proliferation, can cause tumor necrosis in vivo, the tumor volume was reduced or even subside.
(2) TNF directly on the capillary endothelial cells cytotoxicity, can promote angiogenesis, changes in endothelial cell reactivity, stimulation of human vascular endothelial cells to release neutrophil chemotactic factor, the accumulation of neutrophils through the endothelium. Combined with TNF induced adhesion of inflammatory cells the role of the vessel wall, with the cause of blood coagulation, blood flow stops, resulting in tissue necrosis.
(3) TNF-induced tumor necrosis in local inflammatory response to tumor cells is also for LAK lymphokine activated killer cells for short. Function of LAK cells is characterized by the largest antigen without anti-NK cells can not.
(4) TNF in immune regulation mechanism, and enhance sites of inflammation monocyte / macrophage system activity, enhanced NK cells, macrophages, cell toxicity. TNF treatment of cancer of the most important feature is the ability to specifically kill the tumor cells Korea detriment to normal cells, which in the clinical treatment is worthy of attention.
TNF present on colon cancer to clinical trials in the membrane and B-cell lymphoma cancer treatment, and local injection of tumor or treatment of skin cancer, stomach cancer, lung cancer can turn a variety of anti-In vitro generation and freshly isolated tumor cells manifestations of non-specific, broad-spectrum, non-restrictive (could kill the same genotype, allogeneic tumor cells as well as heterogeneous) and selective (on normal lymphocytes and transformed lymphoblastoid cell killing effects of the yuan) is characterized by .
What is a tumor necrosis factor, experiments show that, LAK cells with anti-tumor effects of IL-2 must be combined to display, so l called IL-2/LAK clinical therapy, mainly for renal cell carcinoma, melanoma and other more Several sensitive tumors. IL-2/LAK therapy side effects include fever, chills, skin rash, changes in the central nervous system, liver and kidney dysfunction and bone marrow suppression, the emergence of most of the side effects of using IL-2 and about the same time.