Pulmonary blastoma differential diagnosis with other tumor

By | March 28, 2012

Pulmonary blastoma with other cancer diagnosis a) well-differentiated fetal adenocarcinoma (WDFA): age: WDFA minimum of 12 years; and pulmonary blastoma, 8% of patients younger than 10 years old, mean age 14 years old; incidence: is generally believed that pulmonary blastoma more common than WDFA; Prognosis: Prognosis is good, 5-year survival rate of more than 90%; and pulmonary blastoma 5-year survival rate was 10% -25%; P53: WDFA no variation; and pulmonary blastoma often P53 mutation; Organization: WDFA epithelial component is malignant, benign mesenchymal components; and lung tumor, composed of mesenchymal sarcoma. WDFA Sang very common structure, and occasionally pulmonary blastoma or disappear.
Pulmonary blastoma with other cancer diagnosis 2) Pulmonary blastoma: pulmonary blastoma, microscope with a two-phase structure, but also often occurs in the lungs, it is similar with pulmonary blastoma.
Identification include:
According to the WHO (1999) of histological classification of pulmonary blastoma tumors are malignant epithelial areas of the lung; and pulmonary blastoma is a soft-tissue tumor;
conceptual distinction: eleven biphasic pulmonary blastoma tumor differentiation, with the original epithelial component, similar to well-differentiated fetal adenocarcinoma; its original partnership between the leaf matrix may contain osteosarcoma, osteosarcoma or rhabdomyosarcoma. The eleven cystic pulmonary blastoma and (or) solid sarcoma, benign cyst lining, the ciliated epithelial metaplasia. Clearly, pulmonary blastoma are specific carcinosarcoma, and pulmonary blastoma are lung sarcoma, epithelial metaplasia components, benign cyst;
age: pulmonary blastoma who smoked more common in adults, mean age 43 years; pulmonary blastoma more common in infants and young children 1-4 years old, 10 years of age accounted for 90%;
occurrence site: pulmonary blastoma, occurred in the lung; and pulmonary blastoma, with the exception occurred in the lungs, may also occur in the pleura, mediastinum and other pulmonary tissue;
histological features: pulmonary blastoma with the original epithelium, with morphological characteristics of endometrial glands; its original focal mesenchymal sarcoma with chondrosarcoma, osteosarcoma and rhabdomyosarcoma. The chest is more similar to neuroblastoma rhabdomyosarcoma grape-like structure, especially cystic type;
general expression: pulmonary blastoma as a solid mass; chest showed a cystic Wilms tumor can also as a solid, cystic specimens more than removal of censorship solid;
Immunohistochemical expression: both sarcoma area, on the vimentin-binding protein, myoglobin, S-lOO protein expression of different levels. Pulmonary blastoma, but the organization will also be positive cell antigen expression; and pulmonary blastoma are also a small amount of CK cells were positive. Epithelium, pulmonary blastoma 4CgA and the high rate of positive expression of NSE, calcitonin (calcitonin) is also a small amount of tumor cells were positive. The pulmonary blastoma is only a small number of tumor cells sarcoma areas were positive for NSE;
prognosis: Pulmonary blastoma Pulmonary blastoma prognosis than better.
Pulmonary blastoma with other cancer diagnosis 3) lung sarcoma: pulmonary blastoma and carcinosarcoma same biphasic differentiation of the lung cancer, but both have different. age: cancer sarcoma peak age 60 80 years, 50 years of age accounted for 15%; pulmonary blastoma average age of 43 years, 20 years of age accounted for 20%; Gender: lung sarcoma, more common in men, male to female ratio To 5:1-11 = 1; pulmonary blastoma slightly more common in females, male to female ratio is 1:1-1:2; histological features: non-small cell lung cancer, sarcoma microscope with heterologous sarcoma. Non-small cell carcinoma is a poorly differentiated carcinoma, and most were mixed; sarcoma also more variability asked rhabdomyosarcoma, osteosarcoma, and so on. The JI mother cell lung epithelial part is well differentiated fetal adenocarcinoma, was unity; sarcoma can be differentiated or anaplastic in rhabdomyosarcoma, osteosarcoma or fibrosarcoma; prognosis:
Sarcoma of lung cancer and poor prognosis. The average survival time after lung sarcoma was 9 months, 2 year survival rate <10%; pulmonary blastoma 2-year survival rate of> 30%, 5-year survival rate of 16%. In addition, the pulmonary blastoma but also with mediastinal malignant teratoma and metastatic Wilms, endometrial cancer were identified.

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